RELATIONSHIP BETWEEN THE SERUM BILIRUBIN LEVEL AND THE SPIROMETRIC PARAMETERS IN ADOLESCENTS WITH BRONCHIAL ASTHMA. A PILOT STUDY

Q4 Medicine

Pediatriya - Zhurnal im G.N. Speranskogo Pub Date : 2023-10-13 DOI:10.24110/0031-403x-2023-102-5-13-17

O.S. Boriskina, T.I. Eliseeva, E.V. Tush, R.N. Khramova, S.K. Soodaeva, D.Yu. Ovsyannikov, E.V. Pavlova, A.N. Isharina, N.I. Kubysheva, O.V. Khaletskaya, D.V. Novikov, V.V. Novikov

{"title":"RELATIONSHIP BETWEEN THE SERUM BILIRUBIN LEVEL AND THE SPIROMETRIC PARAMETERS IN ADOLESCENTS WITH BRONCHIAL ASTHMA. A PILOT STUDY","authors":"O.S. Boriskina, T.I. Eliseeva, E.V. Tush, R.N. Khramova, S.K. Soodaeva, D.Yu. Ovsyannikov, E.V. Pavlova, A.N. Isharina, N.I. Kubysheva, O.V. Khaletskaya, D.V. Novikov, V.V. Novikov","doi":"10.24110/0031-403x-2023-102-5-13-17","DOIUrl":null,"url":null,"abstract":"Purpose of the research was to study the relationship between the serum bilirubin level and the spirometric parameters in adolescents with bronchial asthma (BA). Materials and methods used: 213 patients (73,7% boys) with atopic BA aged 10 to 17 y/o were examined. All patients underwent determination of serum bilirubin level, spirometry indicators and general clinical examination. All patients were divided into three groups: G1 of 84 with reduced bilirubin level (less than 10 mсmol/l); G2 of 77 with normal bilirubin level (10 to 17,0 mсmol/l); and G3 of children with slightly elevated bilirubin level (17,1 to 45 mсmol/l). Results: elevated serum bilirubin level in this study occurred in 24.4% (52/213) of patients with BA. As the level of serum bilirubin increased in the general group of patients, a statistically significant increase in the z-criterion of the forced expiratory volume per 1 second (FEV1)/forced vital capacity (FVC) (p=0,005) and the z-criterion of the mean forced expiratory flow during the 25-75% of FVC (p=0,032) was observed, which was confirmed by the revealed positive correlations between the level of bilirubin and these spirometric indicators. The increase in z-criterion FEV1/FVC with an increase in bilirubin levels was statically significant in boys (p=0,046), in girls there was only a tendency to increase this indicator (p=0,07). Conclusion: bronchial patency in patients with slightly elevated bilirubin levels is higher than in patients with reduced serum bilirubin level in the blood. The best characteristics of bronchial patency in patients with “slightly elevated” bilirubin level suggest its protective effect in children with BA.","PeriodicalId":39654,"journal":{"name":"Pediatriya - Zhurnal im G.N. Speranskogo","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatriya - Zhurnal im G.N. Speranskogo","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24110/0031-403x-2023-102-5-13-17","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose of the research was to study the relationship between the serum bilirubin level and the spirometric parameters in adolescents with bronchial asthma (BA). Materials and methods used: 213 patients (73,7% boys) with atopic BA aged 10 to 17 y/o were examined. All patients underwent determination of serum bilirubin level, spirometry indicators and general clinical examination. All patients were divided into three groups: G1 of 84 with reduced bilirubin level (less than 10 mсmol/l); G2 of 77 with normal bilirubin level (10 to 17,0 mсmol/l); and G3 of children with slightly elevated bilirubin level (17,1 to 45 mсmol/l). Results: elevated serum bilirubin level in this study occurred in 24.4% (52/213) of patients with BA. As the level of serum bilirubin increased in the general group of patients, a statistically significant increase in the z-criterion of the forced expiratory volume per 1 second (FEV1)/forced vital capacity (FVC) (p=0,005) and the z-criterion of the mean forced expiratory flow during the 25-75% of FVC (p=0,032) was observed, which was confirmed by the revealed positive correlations between the level of bilirubin and these spirometric indicators. The increase in z-criterion FEV1/FVC with an increase in bilirubin levels was statically significant in boys (p=0,046), in girls there was only a tendency to increase this indicator (p=0,07). Conclusion: bronchial patency in patients with slightly elevated bilirubin levels is higher than in patients with reduced serum bilirubin level in the blood. The best characteristics of bronchial patency in patients with “slightly elevated” bilirubin level suggest its protective effect in children with BA.

查看原文本刊更多论文

青少年支气管哮喘患者血清胆红素水平与肺活量测定指标的关系。一项初步研究

目的探讨青少年支气管哮喘(BA)患者血清胆红素水平与肺活量测定指标的关系。材料和方法:213例10 ~ 17岁特应性BA患者(73.7%为男孩)。所有患者均行血清胆红素水平测定、肺活量测定指标及一般临床检查。所有患者分为三组:G1组84例，胆红素水平降低(小于10 mmol /l);77例胆红素水平正常(10 ~ 17.0 mmol /l);胆红素轻度升高(17、1 ~ 45 mmol /l)。结果:在本研究中，24.4%(52/213)的BA患者血清胆红素水平升高。随着普通组患者血清胆红素水平的升高，1秒用力呼气量(FEV1)/用力肺活量(FVC)的z标准(p= 0.005)和平均用力呼气流量(FVC 25-75%)的z标准(p= 0.032)均有统计学意义的升高，胆红素水平与这些肺活量指标呈正相关，证实了这一点。随着胆红素水平的升高，z-标准FEV1/FVC的增加在男孩中具有统计学意义(p= 0.046)，在女孩中只有增加该指标的趋势(p= 0.07)。结论:胆红素轻度升高患者支气管通畅程度高于血清胆红素降低患者。胆红素“轻度升高”患者支气管通畅的最佳特征提示其对BA患儿的保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Pediatriya - Zhurnal im G.N. Speranskogo Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.60

自引率

0.00%

发文量

150

期刊介绍： Journal “Pediatria” named after G.N. Speransky (the official short names of the Journal are “Journal «Pediatria»,” “Pediatria,” and “«Pediatria,» the Journal”) is the oldest Soviet-and-Russian (in the Russian Federation, the CIS and former Soviet Union) scientific and practical medical periodical assigned for pediatricians that is published continuously since May, 1922, and distributed worldwide. Our mission statement specifies that we aim to the ‘raising the level of skills and education of pediatricians, organizers of children’s health protection services, medicine scientists, lecturers and students of medical institutes for higher education, universities and colleges worldwide with an emphasis on Russian-speaking audience and specific, topical problems of children’s healthcare in Russia, the CIS, Baltic States and former Soviet Union Countries and their determination with the use of the World’s best practices in pediatrics.’ As part of this objective, the Editorial of the Journal «Pediatria» named after G.N. Speransky itself adopts a neutral position on issues treated within the Journal. The Journal serves to further academic discussions of topics, irrespective of their nature - whether religious, racial-, gender-based, environmental, ethical, political or other potentially or topically contentious subjects. The Journal is registered with the ISSN, - the international identifier for serials and other continuing resources, in the electronic and print world: ISSN 0031-403X (Print), and ISSN 1990-2182 (Online). The Journal was founded by the Academician, Dr. Georgiy Nestorovich SPERANSKY, in May, 1922. Now (since 1973) the Journal bears his honorary name.