None Enass J. Waheed1, None Ali M. A. Al-khazraji2, None Awf A. R. Ahmed3
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引用次数: 0
Abstract
The term "nano gold," also known as "gold nanoparticles," is commonly used. These particles are extremely small, with a diameter of less than 100 nm, which is only a fraction of the width of a human hair. Due to their tiny size, nano gold particles are often found in a colloidal solution, where they are suspended in a liquid stabilizer. This colloidal gold is essentially another name for nano gold. The main method for producing gold nanoparticles in a colloidal solution is the citrate synthesis technique, which involves combining different solutions to precipitate the gold nanoparticles[1-5]. In biological systems, copper complexes play a significant role at the active sites of many metalloproteins. These complexes have potential applications in various catalytic processes that occur in living organisms, such as electron transfer reactions and the activation of specific antitumor substances. These processes are relevant in the fields of medicinal chemistry and bioinorganic chemistry. The interaction of copper chelates with biological systems and their noteworthy activities against neoplastic, bacterial, fungal, and cancerous cells are also important. Many copper (II) N, S, O / N, N-donor chelators function as effective anticancer agents due to their ability to bind with DNA base pairs[6-10]. Using hydrophilic gold nanoparticles (AuNPs) as carriers for copper complexes is a novel and purposeful strategy that Could raise these compounds' stability and solubility in H2O aqueous., thus enhancing their bioavailability. The regulated release of Cu-complexes made possible by this method also creates the possibility for fruitful in vivo and in vitro tests. The definition, significance, and numerous applications of copper complexes in connection to nanogold are presented in this review study[11-15].
术语“纳米金”,也被称为“金纳米颗粒”,是常用的。这些颗粒非常小,直径不到100纳米,只有人类头发宽度的一小部分。由于其微小的尺寸,纳米金颗粒通常存在于胶体溶液中,它们悬浮在液体稳定剂中。这种胶体金本质上是纳米金的另一个名字。在胶体溶液中制备金纳米颗粒的主要方法是柠檬酸盐合成技术,该技术涉及将不同的溶液结合在一起沉淀金纳米颗粒[1-5]。在生物系统中,铜配合物在许多金属蛋白的活性位点起着重要的作用。这些配合物在生物体内发生的各种催化过程中有潜在的应用,如电子转移反应和特定抗肿瘤物质的激活。这些过程与药物化学和生物无机化学领域有关。铜螯合物与生物系统的相互作用及其对肿瘤、细菌、真菌和癌细胞的显著活性也很重要。许多铜(II) N, S, O / N, N供体螯合剂由于能够与DNA碱基对结合而成为有效的抗癌剂[6-10]。利用亲水金纳米颗粒(AuNPs)作为铜配合物的载体是一种新颖而有意义的策略,可以提高这些化合物在水中的稳定性和溶解度。,从而提高其生物利用度。通过这种方法使cu复合物的调节释放成为可能,也为有效的体内和体外试验创造了可能。本文综述了铜配合物与纳米金的定义、意义和众多应用[11-15]。