Skin microbiome in cancer patients with pruritus and other skin toxic reactions related to anticancer therapy: A review

Aleksandra S. Polonskaia, Anna V. Michenko, Larisa S. Kruglova, Evgeniya A. Shatokhina, Andrey N. Lvov
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引用次数: 0

Abstract

Modern antitumor therapy includes novel targeted and immunotherapeutic options specifically targeting tumor targets. However, many of these targets are also expressed in the constantly proliferating epidermis of the skin, leading to derangement of proliferation and differentiation of keratinocytes, inflammatory responses, skin barrier dysfunction, inhibition of antimicrobial peptides' synthesis, and toxic skin reactions. The article presents an overview of current data on microbiome disorders associated with toxic skin reactions. The potential mechanisms of skin microbiome changes inducing the occurrence and persistence of rashes during anticancer therapy are addressed.
癌症患者瘙痒和其他与抗癌治疗相关的皮肤毒性反应的皮肤微生物组:综述
现代抗肿瘤治疗包括新的靶向和免疫治疗方案,专门针对肿瘤靶点。然而,这些靶点中的许多也在不断增殖的皮肤表皮中表达,导致角化细胞增殖和分化紊乱、炎症反应、皮肤屏障功能障碍、抗菌肽合成抑制和皮肤毒性反应。这篇文章概述了与皮肤毒性反应相关的微生物组紊乱的当前数据。在抗癌治疗期间,皮肤微生物组变化诱导皮疹发生和持续的潜在机制被解决。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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63
审稿时长
6 weeks
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