A Case of COVID mRNA Vaccine Linked Antiphospholipid Syndrome

Abstract

Introduction: There have been several reports of thrombotic adverse events after administration of the mRNA Covid vaccine [1, 2]. The onset of autoimmune disease has also been reported following viral illness as well as following vaccination [3]. Antiphospholipid syndrome (APS) is an autoimmune hypercoagulable state that can result in thrombotic events such as deep venous thrombosis, pulmonary embolus, and stroke [4]. Antiphospholipid antibodies (aPLs) are associated with APS syndrome. However, not all individuals with aPLs will develop antiphospholipid syndrome as antiphospholipid antibodies are also present in up to 5% of the healthy population. Antiphospholipid antibodies have been reported after infections and vaccines. Antiphospholipid syndrome has also been reported following natural Covid infection [5]. Herein we present a case of antiphospholipid syndrome following Covid mRNA vaccination associated with life-threatening thrombosis, dyspnea, and hypoxia coupled with multiple adverse reactions affecting skin, respiratory, nervous, and vascular systems.