Sleep in pediatric neuromuscular disorders

IF 2.4 4区医学 Q2 CLINICAL NEUROLOGY

Seminars in Pediatric Neurology Pub Date : 2023-12-01 DOI:10.1016/j.spen.2023.101092

John E Pascoe , Alexander Zygmunt , Zarmina Ehsan , Neepa Gurbani

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引用次数: 0

Abstract

Sleep disordered breathing (SDB) is prevalent among children with neuromuscular disorders (NMD). The combination of respiratory muscle weakness, altered drive, and chest wall distortion due to scoliosis make sleep a stressful state in this population. Symptomatology can range from absent to snoring, nocturnal awakenings, morning headaches, and excessive daytime sleepiness. Sequelae of untreated SDB includes cardiovascular effects, metabolic derangements, and neurocognitive concerns which can be compounded by those innate to the NMD. The clinician should have a low threshold for obtaining polysomnography and recognize the nuances of individual disorders due to disproportionately impacted muscle groups such as hypoventilation in ambulating patients from diaphragm weakness. Non-invasive or invasive ventilation are the mainstay of treatment. In this review we explore the diagnosis and treatment of SDB in children with various NMD.

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睡眠对小儿神经肌肉疾病的影响

睡眠呼吸紊乱（SDB）在患有神经肌肉疾病（NMD）的儿童中非常普遍。呼吸肌无力、驱动力改变以及脊柱侧弯导致的胸壁变形，这些因素结合在一起，使这一人群的睡眠处于紧张状态。症状包括无鼾、打鼾、夜醒、晨起头痛和白天过度嗜睡。未经治疗的 SDB 后果包括心血管影响、新陈代谢失调和神经认知问题，这些问题可能因 NMD 的先天性症状而变得更加复杂。临床医生应降低获取多导睡眠图的门槛，并认识到由于肌肉群受到不成比例的影响而导致的个别疾病的细微差别，例如膈肌无力导致步行患者通气不足。无创或有创通气是治疗的主要方法。在本综述中，我们将探讨各种 NMD 儿童 SDB 的诊断和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Pediatric Neurology CLINICAL NEUROLOGY-PEDIATRICS

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

84 days

期刊介绍： Seminars in Pediatric Neurology is a topical journal that focuses on subjects of current importance in the field of pediatric neurology. The journal is devoted to making the status of such topics and the results of new investigations readily available to the practicing physician. Seminars in Pediatric Neurology is of special interest to pediatric neurologists, pediatric neuropathologists, behavioral pediatricians, and neurologists who treat all ages.