Correlation between LRG1 and Adipokines in Psoriasis

IF 3.7 4区医学 Q1 DERMATOLOGY

Dermatologic Therapy Pub Date : 2023-10-03 DOI:10.1155/2023/6689580

Keshuai Liu, Lanzhi Li, Yue Li, Xingwu Duan, Hailing Dong, Ziqing You

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Abstract

Background and Objective. Patients with psoriasis may exhibit abnormal changes in serum adipokine levels, which are often related to disease severity of the disease. Leucine-rich alpha-2-glycoprotein 1 (LRG1) is an acute-phase inflammatory protein that may be linked to adipokines in psoriasis. In this study, we evaluated the differences in the expression of adipokines and LRG1 between patients with psoriasis and healthy individuals, analyzed the correlation between the expression of LRG1 and adipokines, and explored their relationship with psoriatic lesions. Methods. In this cross-sectional study, patients with psoriasis (n = 54) and healthy controls (n = 26) were enrolled, and their clinical characteristics were recorded. Fasting venous blood samples were collected from each participant. The serum concentrations of leptin, resistin, adiponectin, and LRG1 in each sample were measured using the enzyme-linked immunosorbent assay. Results. The study included 54 patients with psoriasis vulgaris and 26 healthy controls. The serum levels of LRG1, leptin, and resistin were significantly higher in patients with psoriasis than in healthy controls. Conversely, adiponectin levels were significantly lower in patients with psoriasis. The study showed that LRG1 expression was positively correlated with leptin and resistin expression but negatively correlated with adiponectin expression. Interestingly, only leptin, resistin, and LRG1 expression showed a linear correlation with the Psoriasis Area and Severity Index (PASI). When we categorized patients with psoriasis based on their LRG1 levels, we observed that the group with high LRG1 levels showed a higher PASI. Conclusions. We observed a significant correlation between LRG1 and adipokine expression in patients with psoriasis. In addition, the expression levels of LRG1, leptin, and resistin were observed to be correlated with the severity of psoriasis. We believe that the occurrence and development of psoriasis are collectively influenced by LRG1 and leptin/resistin expression.

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银屑病LRG1与脂肪因子的相关性研究

背景和目的。牛皮癣患者可能表现出血清脂肪因子水平的异常变化，这通常与疾病的严重程度有关。富含亮氨酸的α -2糖蛋白1 (LRG1)是一种急性期炎症蛋白，可能与牛皮癣中的脂肪因子有关。在本研究中，我们评估了牛皮癣患者与健康人群中脂肪因子和LRG1的表达差异，分析了LRG1与脂肪因子表达的相关性，并探讨了它们与牛皮癣病变的关系。方法。在这项横断面研究中，入选了54例牛皮癣患者和26例健康对照者，并记录了他们的临床特征。从每个参与者身上采集空腹静脉血样本。采用酶联免疫吸附法测定各组血清中瘦素、抵抗素、脂联素和LRG1的浓度。结果。该研究包括54名寻常型牛皮癣患者和26名健康对照者。银屑病患者血清LRG1、瘦素和抵抗素水平明显高于健康对照组。相反，牛皮癣患者的脂联素水平明显较低。研究表明，LRG1表达与瘦素、抵抗素表达呈正相关，与脂联素表达负相关。有趣的是，只有瘦素、抵抗素和LRG1的表达与银屑病面积和严重程度指数(PASI)呈线性相关。当我们根据LRG1水平对银屑病患者进行分类时，我们观察到LRG1水平高的组表现出更高的PASI。结论。我们观察到银屑病患者中LRG1与脂肪因子表达之间存在显著相关性。此外，LRG1、瘦素和抵抗素的表达水平与银屑病的严重程度相关。我们认为银屑病的发生和发展受LRG1和瘦素/抵抗素表达的共同影响。

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来源期刊

Dermatologic Therapy 医学-皮肤病学

CiteScore

7.00

自引率

8.30%

发文量

711

审稿时长

3 months

期刊介绍： Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.