Therapeutic Effect and Mechanism of Glabridin Liposome on Imiquimod-induced Mice Psoriasis

IF 0.6 4区 医学 Q4 CHEMISTRY, MEDICINAL
Yongjie Lu, Lushi Cheng, Lu Ren, Dongqiu Chen, Shumin Guan, Siyang Zhu, Xian Xu, Bing Zhang, Minghui Tang, Chijian Zhang, Yong Ai, Lanyue Zhang, Tinggang He
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引用次数: 0

Abstract

Background Glabridin is one of the main components of the isoflavonoids in Glycyrrhiza glabra and possesses anti-inflammatory, antibacterial, and anticancer effects. Objectives Herein, the therapeutic effects and mechanisms of action of the glabridin liposome (GL) complex were studied in mice with imiquimod-induced psoriasis. Materials and Methods After treatment with GLs, their effectiveness was assessed using parameters, such as Psoriasis Area and Severity Index (PASI) score, histopathology, inflammatory cytokines, and psoriasis-associated proteins. Results The results demonstrated that GLs could significantly improve psoriatic symptoms, downregulate mast cell infiltration, and significantly reduce the PASI score of psoriatic mice. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) results showed that GLs significantly decreased IL-23 and STAT3 mRNA expression. The results of immunohistochemistry and the enzyme-linked immunosorbent assay indicated that GLs decreased the expression of tumor necrosis factor-alpha (TNF-α), IL-17, and IL-22. Conclusion GLs can alleviate psoriasis by inhibiting the expression of keratinocyte-activating proteins. These results suggest that GLs have great potential for the clinical treatment of psoriasis.
光甘草定脂质体治疗吡喹莫德致小鼠银屑病的疗效及机制
光甘草定是光甘草中异黄酮类化合物的主要成分之一,具有抗炎、抗菌、抗癌等作用。目的研究光甘草定脂质体(GL)复合物对吡喹莫德致银屑病小鼠的治疗作用及其机制。材料和方法使用GLs治疗后,使用诸如银屑病面积和严重程度指数(PASI)评分、组织病理学、炎症细胞因子和银屑病相关蛋白等参数评估其有效性。结果GLs能显著改善银屑病症状,下调肥大细胞浸润,显著降低银屑病小鼠PASI评分。定量逆转录聚合酶链反应(RT-qPCR)结果显示,GLs显著降低IL-23和STAT3 mRNA的表达。免疫组化和酶联免疫吸附实验结果显示,GLs可降低肿瘤坏死因子α (TNF-α)、IL-17和IL-22的表达。结论GLs可通过抑制角质形成细胞活化蛋白的表达来缓解银屑病。这些结果表明,GLs在银屑病的临床治疗中具有很大的潜力。
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来源期刊
Pharmacognosy Magazine
Pharmacognosy Magazine CHEMISTRY, MEDICINAL-
CiteScore
1.87
自引率
0.00%
发文量
37
审稿时长
3 months
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