Prescription audit and drug interactions of anti-diabetic drugs at Outpatient Department at a tertiary care teaching hospital in Eastern Nepal

Prabina Shrestha, Anil Kumar Sah, Kadir Alam, Deependra Prasad Sarraf, Shyam Kumar Mallik
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Abstract

Type 2 diabetes mellitus (T2DM) is the third major non-communicable disease in Nepal. Drug utilization studies help in reducing the patient’s expenditure, adverse drug reactions and drug-drug interactions. It would help in understanding of consumption of drugs including newer ones. Objective was to analyze the prescribing pattern and drug interactions of anti-diabetic drugs. A prospective cross-sectional study was conducted among patients having T2DM at Birat Medical College and Teaching Hospital (BMCTH), Biratnagar, Nepal from May 2019- August 2019. WHO core drug use indicators were used to analyze the obtained data. Descriptive statistics like mean, standard deviation, frequency and percentage were calculated using Microsoft Excel 2013. Out of 200 patients, 104 (52.0%) were females and 49.5% were from the age group of 41-60 years. Average number of drugs per patient was 5.74. Biguanides (40.7%) were the most common prescribed oral antidiabetic drugs followed by Sulfonylureas (23.3%). The percentage of drugs prescribed by generic name and from WHO essential drug list was 0.6% and 15.4% respectively. A total of 95 (47.5%) patients has potential drug-drug interaction (DDI) and it was most common in the age group of 41-60 years (43.2%). Among 95 DDI, Metformin+Amlodipine ranked in 1st position (16 encounters). Polypharmacy was prevalent in the present study. Metformin was the most commonly prescribed anti-diabetic drug. The percentage of drugs from the WHO essential medicine list and prescribed by generic names was low. Prevalence of potential DDI was high.
尼泊尔东部某三级护理教学医院门诊部抗糖尿病药物处方审核及药物相互作用
2型糖尿病(T2DM)是尼泊尔第三大非传染性疾病。药物利用研究有助于减少患者的支出,药物不良反应和药物-药物相互作用。这将有助于了解药物的消费情况,包括新药物。目的分析降糖药的处方模式及药物相互作用。2019年5月至2019年8月,在尼泊尔比拉特纳格尔比拉特医学院和教学医院(BMCTH)对2型糖尿病患者进行了一项前瞻性横断面研究。采用世卫组织核心药物使用指标对获得的数据进行分析。使用Microsoft Excel 2013进行均值、标准差、频率、百分比等描述性统计。200例患者中,女性104例(52.0%),年龄在41-60岁的患者占49.5%。患者平均使用药物5.74种。最常见的口服降糖药是双胍类药物(40.7%),其次是磺脲类药物(23.3%)。按通用名开具处方的药物和按世卫组织基本药物清单开具处方的药物所占比例分别为0.6%和15.4%。95例(47.5%)患者存在潜在药物-药物相互作用(DDI),以41 ~ 60岁年龄组最为常见(43.2%)。在95次DDI中,二甲双胍+氨氯地平排在第1位(16次)。在本研究中,多种用药是普遍存在的。二甲双胍是最常用的抗糖尿病药物。来自世卫组织基本药物清单和按通用名称开具处方的药物的百分比很低。潜在DDI患病率高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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