Inhibin A may be the Black Horse for Determination of the Optimal Triggering Time and Decision-making for Oocyte Retrieval

Abstract

Objectives: Assessment of the applicability of estimated serum inhibin A (INHA) and/or INHB versus estradiol (E2) levels to determine the triggering time during controlled ovarian stimulation (COS) that might allow the retrieval of the optimal number of oocytes. Patients: 196 infertile women assigned to receive COS for ELISA estimation of serum levels of E2 and INHs on day-2 of the cycle and on the day of retrieval depending on having serum E2 levels >2000 pg/ml and the optimal The study outcome is the blinded distinguishing ability of estimated serum levels of E2 and INHs between cases that might have <11, 11-13, and 14-15 mature follicles on transvaginal ultrasonography (TUV) imaging on the day of triggering. Results: Serum E2 levels at the time of triggering (>2000 differentiation between patients according to the number of mature follicles compared to serum E2 and INHB differentiating patients had <11 or >14 mature follicles, while E2 and INHB failed for this respect. Statistical for canceling depending on the maturation of a low number of follicles after COS and for the presence of 14-15 mature follicles and deciding triggering and oocyte retrieval. Conclusion: Estimation of serum E2 is an unreliable marker for differentiating women according to several