7 Paracrine regulation of follicular maturation in primates

Abstract

Taken together, the studies reviewed here suggest that although gonadotropins are necessary for follicular growth, they are insufficient by themselves to explain the dynamics of folliculogenesis. Indeed, the role of gonadotropins in follicular maturation must necessarily be permissive: that is LH and FSH initiate a synchronized cascade of follicular events directly mediated by paracrine and autocrine factors.