Formulation and Evaluation of Topical Nano-Hydrogel of Zinc and Annona Muricata Extract

Abstract

A scientific method is essential for phytochemists to deliver active ingredients in a consistent manner. This can be accomplished through the development of novel drug delivery systems for active plant compounds. The current study aims to prepare Annona muricata leaves extract (ALE) containing nano zinc formulation into a nano-particulate hydrogel. The active components were extracted by cold maceration of Anona muricata leaves in ethanol and then converted into polymeric nanoparticles by gelation method based on electrostatic interaction between the Hydroxyl Amine on Chitosan and a cluster of negative charge from the polyanion NaTPP. Zinc oxide nano particles (ZNPs) was formulated by precipitating zinc acetate with sodium hydroxide. These were then incorporated with Carbopol-940 to generate the gel matrix. The result demonstrated that polymeric nanoparticles are closely spherical in shape with a z-average 358.45 ± 11.3 nm and PDI in the range of 0.440-0.812. The gels exhibited a high viscosity, a neutral pH, and acceptable spreadability. Furthermore, a stability assay demonstrates that it has chemical stability and does not cause skin irritation, making it appropriate for transdermal delivery.