Research Progress of UBE2S in Digestive Sys-tem Tumors

Abstract

Ubiquitin-conjugating enzyme 2S (UBE2S), as a member of Ubiquitin-conjugating enzyme (E2) family, is an ubiquitin ligase regulated by cell cycle. It is specifically expressed in digestive system tumors, and its expression level is significantly higher than that in adjacent tissues. At the same time, patients with high UBE2S expression have poor prognosis. Studies have shown that UBE2S plays a promoting role in digestive system tumors such as oral squamous cell carcinoma, esophageal carcinoma, gastric cancer, liver cancer, gallbladder cancer and pancreatic cancer, so UBE2S