The Effect of Inflammatory Markers in the Hemogram Parameters of Pregnant Women with Thyroid Disease on Obstetric and Neonatal Outcomes

Q4 Medicine
Funda DEMİREL, Ünal TURKAY
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Abstract

Aim: This study aimed to determine the differences in hemogram parameters, especially in inflammatory markers and perinatal and neonatal outcomes of pregnant women with thyroid disease, and to examine the effects of these differences on pregnancy outcomes. Material and Methods: The data of 80 pregnant women diagnosed with thyroid disease according to the American Thyroid Association (ATA) criteria at the first admission between 2016 and 2019 and 100 pregnant women whose thyroid hormone levels were within the normal reference range were retrospectively analyzed. Obstetric outcomes such as type and time of delivery, and the presence of additional disease during pregnancy, and neonatal outcomes such as weight, gender, and Apgar score at birth were compared. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), white blood cell (WBC) count, and hemoglobin (Hb) and mean platelet volume (MPV) values, which are accepted as inflammation markers, were also compared between groups. Results: There was no significant difference between hypothyroid and hyperthyroid pregnant women in terms of Hb (p=0.319) and PLR (p=0.341) values. Third-trimester WBC (p=0.015) values were higher and MPV (p=0.007) values were lower in the hypothyroid pregnant women compared to the control group. The highest NLR (p=0.005) value was observed in the hypothyroid group. Comorbidities were found to be 27.4% (n=20) in the hypothyroid group, 14.3% (n=1) in the hyperthyroid group, and 1.0% (n=1) in the control group (p<0.001). Conclusion: Pregnant women with thyroid disease may have differences in hemogram parameters, especially in inflammatory markers, and these differences may affect pregnancy outcomes.
甲状腺疾病孕妇血象参数中炎症标志物对产科和新生儿结局的影响
目的:本研究旨在确定甲状腺疾病孕妇血象参数的差异,特别是炎症标志物和围产期及新生儿结局,并探讨这些差异对妊娠结局的影响。材料与方法:回顾性分析2016 - 2019年首次入院按美国甲状腺协会(ATA)标准诊断为甲状腺疾病的80例孕妇和甲状腺激素水平在正常参考范围内的100例孕妇的资料。比较了分娩类型和时间、妊娠期间是否存在其他疾病等产科结局,以及出生时体重、性别和Apgar评分等新生儿结局。比较两组间中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、白细胞(WBC)计数、血红蛋白(Hb)和平均血小板体积(MPV)等炎症指标。结果:甲状腺功能低下与甲状腺功能亢进孕妇Hb (p=0.319)、PLR (p=0.341)值差异无统计学意义。甲状腺功能减退孕妇妊娠晚期WBC值(p=0.015)高于对照组,MPV值(p=0.007)低于对照组。甲状腺功能减退组NLR最高(p=0.005)。甲状腺功能减退组合并症发生率为27.4% (n=20),甲状腺功能亢进组为14.3% (n=1),对照组为1.0% (n=1) (p = amp;lt;0.001)。结论:甲状腺疾病孕妇在血象参数,尤其是炎症标志物方面可能存在差异,这些差异可能影响妊娠结局。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Duzce Medical Journal
Duzce Medical Journal Medicine-Medicine (all)
CiteScore
0.60
自引率
0.00%
发文量
59
审稿时长
12 weeks
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