Date (Phoenix dactylifera L.) Fruits as a Potential Lipid-Lowering Therapy: Effect on High-Fat Diet and Triton-WR-1339-Induced Hyperlipidemic Rats

Eimad Dine Tariq Bouhlali, Abdelbassat Hmidani, Bouchra Bourkhis, Zineb Moussafir, Younes Filali-Zegzouti, Chakib Alem
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Abstract

The present study was designed to establish the phenolic profile and explore the potential lipid-lowering effect of two Moroccan date fruit varieties (Majhoul and Bousrdoun). HPLC-DAD has been used for phenolic profiling. Lipid peroxidation was measured in terms of thiobarbituric acid-reactive substances (TBARS) by using egg yolk homogenate as lipid-rich media. The anti-hyperlipidemic effect of the methanolic extract was examined using both models Triton-WR-1339 and chronic high-fat-diet-induced hyperlipemic rats. Further, the serum lipid profile was determined. The HPLC-DAD analysis revealed the presence of seven phenolic acids and three flavonoids, of which gallic, caffeic acids and rutin were found to be the most abundant compounds. The gathered results indicate that rats treated with both varieties showed a significant decrease in serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels as well as an increase in high-density lipoprotein cholesterol levels compared with Triton and high-fat diet controls. Moreover, a significant decrease in body weight was observed in the date-treated groups when compared to the hyperlipidemic control group. A thiobarbituric acid reactive substances test showed that these extracts significantly inhibited lipid peroxidation. Bousrdoun, which showed the highest lipid-lowering effects, is the one that displayed the greatest inhibition of lipid peroxidation and contains the largest amount of caffeic, p-coumaric, gallic, vanillic acids, rutin and luteolin. Accordingly, dates could be used as a potential functional food, which may be used to prevent lipid disorders and oxidation.
枣(凤凰花)水果作为一种潜在的降脂疗法:对高脂肪饮食和triton - wr -1339诱导的高脂血症大鼠的影响
本研究旨在建立两种摩洛哥枣品种(Majhoul和bousrdown)的酚类特征,并探讨其潜在的降脂作用。HPLC-DAD已用于酚类分析。以蛋黄匀浆为富脂介质,用硫代巴比妥酸反应物质(TBARS)测定脂质过氧化。采用Triton-WR-1339模型和慢性高脂饮食诱导的高脂血症大鼠研究了甲醇提取物的抗高脂血症作用。进一步测定血清脂质谱。HPLC-DAD分析结果显示,黄酮类化合物含量最高,其中没食子酸、咖啡酸和芦丁含量最高。收集到的结果表明,与Triton和高脂肪饮食对照组相比,服用这两种品种的大鼠的血清总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平显著降低,高密度脂蛋白胆固醇水平显著升高。此外,与高脂血症对照组相比,吃枣组的体重显著下降。硫代巴比妥酸活性物质试验表明,这些提取物明显抑制脂质过氧化。bousrdown的降脂效果最好,对脂质过氧化的抑制作用最强,且含有最多的咖啡酸、对香豆酸、没食子酸、香草酸、芦丁和木犀草素。因此,枣可以作为一种潜在的功能性食品,用于预防脂质紊乱和氧化。
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