The Impact of COVID-19 Vaccination on Bulgarian Patients with Uncomplicated Type 2 Diabetes Mellitus as the Only Chronic Condition

Q4 Medicine

Acta Medica Bulgarica Pub Date : 2023-09-01 DOI:10.2478/amb-2023-0025

T. Valkov, G. Dimitrov

{"title":"The Impact of COVID-19 Vaccination on Bulgarian Patients with Uncomplicated Type 2 Diabetes Mellitus as the Only Chronic Condition","authors":"T. Valkov, G. Dimitrov","doi":"10.2478/amb-2023-0025","DOIUrl":null,"url":null,"abstract":"Abstract Objective: This retrospective study aimed to investigate the impact of COVID-19 vaccination on Bulgarian patient cohorts with uncomplicated diabetes mellitus type 2 as the only documented chronic comorbidity. We conducted a comparison of fully vaccinated and non-vaccinated populations, considering gender, age groups and vaccine type, across ambulatory, hospital, and ICU settings. Design: Between March 2020 and June 2022, a comprehensive retrospective analysis was conducted on a national level, utilizing data from the Ministry of Health of the Republic of Bulgaria database obtained after a formal written request. The study included a total of 1,126,946 confirmed COVID-19 patients. Results: Among the 1,126,946 confirmed COVID-19 patients, 3,792 individuals (0.33% of the total confirmed cases) had diabetes mellitus as a single chronic condition. Among the 247,441 hospitalized COVID-19 cases, 1,382 patients (0.56% of the total) had type 2 diabetes mellitus. Notably, the majority of patients requiring hospitalization due to supplemental oxygen requirement were unvaccinated women aged between 60 and 69, accounting for 240 patients. The highest mortality rates were observed in both unvaccinated men and women aged between 70 and 79, with 88 patients in each group. Statistical analysis revealed significant findings in favor of reduced rates of ambulatory care [OR = 0.76 (95% CI 0.6471 to 0.8891); p = 0.0006], intensive care admission [OR = 0.38 (95% CI 0.2698 to 0.5282); p < 0.0001], in-hospital mortality [OR = 0.18 (95% CI 0.0864 to 0.3604); p < 0.0001], and ICU-related mortality [OR = 0.17 (95% CI 0.0893 to 0.3436); p < 0.0001]. The vaccinated cohorts who received BNT162b2 demonstrated the lowest observed death rates, with 9 deaths out of 485 individuals (1.8%) across all age groups. Conclusion: In conclusion, this retrospective analysis indicates reduced mortality in patients with uncomplicated type II diabetes mellitus who received vaccination against SARS-CoV-2. Vaccinated individuals also showed significant reduction in ICU admissions.","PeriodicalId":35746,"journal":{"name":"Acta Medica Bulgarica","volume":"2 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Medica Bulgarica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2478/amb-2023-0025","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Abstract Objective: This retrospective study aimed to investigate the impact of COVID-19 vaccination on Bulgarian patient cohorts with uncomplicated diabetes mellitus type 2 as the only documented chronic comorbidity. We conducted a comparison of fully vaccinated and non-vaccinated populations, considering gender, age groups and vaccine type, across ambulatory, hospital, and ICU settings. Design: Between March 2020 and June 2022, a comprehensive retrospective analysis was conducted on a national level, utilizing data from the Ministry of Health of the Republic of Bulgaria database obtained after a formal written request. The study included a total of 1,126,946 confirmed COVID-19 patients. Results: Among the 1,126,946 confirmed COVID-19 patients, 3,792 individuals (0.33% of the total confirmed cases) had diabetes mellitus as a single chronic condition. Among the 247,441 hospitalized COVID-19 cases, 1,382 patients (0.56% of the total) had type 2 diabetes mellitus. Notably, the majority of patients requiring hospitalization due to supplemental oxygen requirement were unvaccinated women aged between 60 and 69, accounting for 240 patients. The highest mortality rates were observed in both unvaccinated men and women aged between 70 and 79, with 88 patients in each group. Statistical analysis revealed significant findings in favor of reduced rates of ambulatory care [OR = 0.76 (95% CI 0.6471 to 0.8891); p = 0.0006], intensive care admission [OR = 0.38 (95% CI 0.2698 to 0.5282); p < 0.0001], in-hospital mortality [OR = 0.18 (95% CI 0.0864 to 0.3604); p < 0.0001], and ICU-related mortality [OR = 0.17 (95% CI 0.0893 to 0.3436); p < 0.0001]. The vaccinated cohorts who received BNT162b2 demonstrated the lowest observed death rates, with 9 deaths out of 485 individuals (1.8%) across all age groups. Conclusion: In conclusion, this retrospective analysis indicates reduced mortality in patients with uncomplicated type II diabetes mellitus who received vaccination against SARS-CoV-2. Vaccinated individuals also showed significant reduction in ICU admissions.

查看原文本刊更多论文

COVID-19疫苗接种对保加利亚无并发症2型糖尿病患者的影响

摘要目的:本回顾性研究旨在探讨COVID-19疫苗接种对保加利亚无并发症2型糖尿病患者队列的影响，2型糖尿病是唯一记录的慢性合并症。考虑到性别、年龄组和疫苗类型，我们在门诊、医院和ICU环境中对完全接种疫苗和未接种疫苗的人群进行了比较。设计:在2020年3月至2022年6月期间，利用保加利亚共和国卫生部在正式书面请求后获得的数据库中的数据，在国家一级进行了全面的回顾性分析。该研究共纳入了1126946名新冠肺炎确诊患者。结果:1,126,946例新冠肺炎确诊患者中，有3,792例(占确诊病例总数的0.33%)合并糖尿病为单一慢性病。247441例新冠肺炎住院患者中，2型糖尿病1382例(占0.56%)。值得注意的是，大多数因补充氧气需要住院的患者是60至69岁的未接种疫苗的妇女，占240例患者。70至79岁未接种疫苗的男性和女性死亡率最高，每组88名患者。统计分析显示显著的结果有利于降低门诊护理率[OR = 0.76 (95% CI 0.6471 ~ 0.8891);p = 0.0006]，重症监护住院[OR = 0.38 (95% CI 0.2698 ~ 0.5282);p & lt;0.0001]，住院死亡率[OR = 0.18 (95% CI 0.0864 ~ 0.3604);p & lt;0.0001]， icu相关死亡率[OR = 0.17 (95% CI 0.0893 ~ 0.3436);p & lt;0.0001]。接受BNT162b2疫苗接种的队列显示观察到的死亡率最低，在所有年龄组的485人中有9人死亡(1.8%)。结论:本回顾性分析表明，接受SARS-CoV-2疫苗接种的无并发症II型糖尿病患者死亡率降低。接种疫苗的个体ICU入院率也显著降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Acta Medica Bulgarica Medicine-Medicine (all)

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

25 weeks

期刊介绍： About 30 years ago - in 1973, on the initiative of the Publishing House „Medicine and Physical Culture", namely its former director Mr. Traian Ivanov, the Ministry of Health set up and accepted to subsidize a new medical magazine that was to be published only in the English language and had to reflect the status and the achievements of the Bulgarian medical science. Thus the language barrier was overcome and stable relations were established with the international medical society, large libraries, and university centers. The famous internationally known scientist professor Assen A. Hadjiolov was elected edition-in-chief by the first editorial staff and the magazine was named Acta Medica Bulgarica.