How Sensitive and Specific are Rapid Antigen Tests for SARS-CoV-2 – The Experience of One of the Biggest Bulgarian Hospitals

Q4 Medicine

Acta Medica Bulgarica Pub Date : 2023-09-01 DOI:10.2478/amb-2023-0035

D. Niyazi, T. Todorova, Zh. Stoykova, Ts. Kostadinova, M. Bozhkova, T. Stoeva

引用次数: 0

Abstract

Abstract Rapid point-of-care tests that detect antigens specific for SARS-CoV-2 are less expensive and faster than the standard molecular methods. However, their accuracy varies widely between tests, populations and settings. We decided to assess the diagnostic precision of antigen tests for SARS-CoV-2 in a real-life hospital environment. In a cohort of 2677 hospitalized patients, we found a sensitivity of 60.2% (95% CI 57.1%-63.4%) and a specificity of 98.1% (95% CI 97.4%-98.7%) for the antigen tests when compared to RT-PCR. The accuracy of antigen testing could be acceptable in a hospital setting, especially when the result is consistent with the clinical and epidemiological context. When there is discordance between the antigen test result and the patient’s symptoms, a confirmation with molecular methods is needed.

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快速抗原检测对SARS-CoV-2的敏感性和特异性有多高——保加利亚一家最大医院的经验

与标准分子方法相比，检测SARS-CoV-2特异性抗原的快速即时检测方法更便宜、更快。然而，它们的准确性在测试、人群和环境之间差异很大。我们决定在真实的医院环境中评估抗原检测对SARS-CoV-2的诊断精度。在2677名住院患者的队列中，我们发现与RT-PCR相比，抗原检测的敏感性为60.2% (95% CI 57.1%-63.4%)，特异性为98.1% (95% CI 97.4%-98.7%)。抗原检测的准确性在医院环境中是可以接受的，特别是当结果与临床和流行病学背景一致时。当抗原检测结果与患者症状不一致时，需要用分子方法进行确认。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Medica Bulgarica Medicine-Medicine (all)

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

25 weeks

期刊介绍： About 30 years ago - in 1973, on the initiative of the Publishing House „Medicine and Physical Culture", namely its former director Mr. Traian Ivanov, the Ministry of Health set up and accepted to subsidize a new medical magazine that was to be published only in the English language and had to reflect the status and the achievements of the Bulgarian medical science. Thus the language barrier was overcome and stable relations were established with the international medical society, large libraries, and university centers. The famous internationally known scientist professor Assen A. Hadjiolov was elected edition-in-chief by the first editorial staff and the magazine was named Acta Medica Bulgarica.