Measurement of Electrophysiology, Sexual Dysfunction, and Cognitive Impairment in Patients With Diabetes Referred for Neuropathy Symptoms: A Case-Control Study

Journal of Neurology Research Pub Date : 2023-09-01 DOI:10.14740/jnr752

Leila Simani, Muhanna Kazempour, Mahtab Ramezani, Faezeh Maghsudloo, Hasan Kazazi, Sahar Abedi, Zahra Fatehi, Fatemeh Ghorbani, Ehsan Karimialavijeh

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Abstract

Background: The association between diabetic neuropathy, cognitive impairment, and sexual dysfunction together in patients with diabetes mellites (DM) is not assessed in prior studies. This study aimed to investigate the association between all these microvascular complications of DM. Methods: A cross-sectional study was conducted on 162 participants (110 diabetic patients and 52 non-diabetic subjects). Neuropathy was evaluated by neuropathy disability score (NDS) and neuropathy symptom score (NSS). Nerve conduction study (NCS), sural and radial sensory nerve action potential, sural/radial nerve amplitude ratio (SRAR), and tibial compound muscle action potential were measured. Participants underwent cognitive and sexual assessments by Montreal cognitive assessment (MoCA), Beck depression score, female sexual function index, and the male sexual function index questionnaires. Results: Both groups showed a decline in cognitive functions; however, diabetic patients had a significantly lower score in MoCA compared to the non-diabetic group (mean ± standard deviation: 20.98 ± 5.07, 23.17 ± 4.47; P value < 0.001). No statistical difference was observed regarding sexual activity (P value = 0.12 and 0.39 for female and male sexual function index), and Beck score (mean ± standard deviation: 8.56 ± 6.47, 8.96 ± 4.74; P value = 0.451) between the two groups. The NCS parameters were notably different in both groups. There were no differences between NCS, NDS, and NSS findings and sexual function. Conclusions: Our data suggest that NCS parameters, even SRAR, do not necessarily correlate with cognitive performance and sexual function. Sexual dysfunction was not correlated with diabetic neuropathy, but clinical findings of NDS and NSS showed a modestly negative correlation with cognitive function. J Neurol Res. 2023;13(1):50-55 doi: https://doi.org/10.14740/jnr752

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糖尿病患者神经病变症状的电生理、性功能障碍和认知障碍测量:一项病例对照研究

背景:糖尿病神经病变、认知障碍和性功能障碍在糖尿病患者(DM)中的相关性在先前的研究中未被评估。本研究旨在探讨糖尿病所有微血管并发症之间的关系。方法:对162名参与者(110名糖尿病患者和52名非糖尿病患者)进行横断面研究。采用神经病变失能评分(NDS)和神经病变症状评分(NSS)评价神经病变。测量神经传导研究(NCS)、腓肠和桡侧感觉神经动作电位、腓肠/桡神经振幅比(SRAR)、胫骨复合肌动作电位。采用蒙特利尔认知评估(MoCA)、贝克抑郁评分、女性性功能指数和男性性功能指数问卷对受试者进行认知和性方面的评估。结果:两组患者认知功能下降;然而，糖尿病患者的MoCA评分明显低于非糖尿病组(平均±标准差:20.98±5.07,23.17±4.47;P值<0.001)。性活动(男女性功能指数P值分别为0.12和0.39)、Beck评分(均数±标准差分别为8.56±6.47、8.96±4.74;P值= 0.451)。两组NCS参数差异有统计学意义。NCS、NDS和NSS的结果与性功能没有差异。结论:我们的数据表明，NCS参数，甚至是SRAR，与认知表现和性功能并不一定相关。性功能障碍与糖尿病神经病变无相关性，但NDS和NSS的临床表现与认知功能呈中度负相关。中华神经科学杂志，2013;13(1):50-55 doi: https://doi.org/10.14740/jnr752

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Journal of Neurology Research

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