Sara Ristevska, Hristina Litovin, Hrisanta Godzo, Teodora Tasevska, Lina Livrinska, Nikola Geskovski, Katerina Goracinova, Kristina Mladenovska, Renata Slaveska Raichki, Marija Glavash Dodov, Maja Simonoska Crcarevska
{"title":"Effect of surfactant stabilizers on physico-chemical properties of PLGA nanoparticles loaded with tetrahydrocannabinol","authors":"Sara Ristevska, Hristina Litovin, Hrisanta Godzo, Teodora Tasevska, Lina Livrinska, Nikola Geskovski, Katerina Goracinova, Kristina Mladenovska, Renata Slaveska Raichki, Marija Glavash Dodov, Maja Simonoska Crcarevska","doi":"10.33320/maced.pharm.bull.2023.69.03.143","DOIUrl":null,"url":null,"abstract":"In the past years the Cannabis sativa extract has been extensively studied. Its` main components THC, or delta9-tetrahydrocannabinol and cannabidiol are widely researched due to their potential therapeutic benefits such as anti-inflammatory, immunomodulatory, neuroprotective, antioxidant, antiemetic activity etc. However, the limitations for THC medicinal use are related to its` bioavailability challenges such as poor water solubility and peroral bioavailability, rapid metabolism, fast initial half‐life (approximately 6 min) and high protein binding (Lucas et al., 2018). These problems might be overcome by encapsulation of THC into drug delivery carriers, such as nanoparticles. The aim of this study was to design and characterize PLGA nanoparticles loaded with THC by emulsion-based preparation method using two different surfactants as stabilizers.","PeriodicalId":30550,"journal":{"name":"Makedonsko Farmacevtski Bilten","volume":"6 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Makedonsko Farmacevtski Bilten","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33320/maced.pharm.bull.2023.69.03.143","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
In the past years the Cannabis sativa extract has been extensively studied. Its` main components THC, or delta9-tetrahydrocannabinol and cannabidiol are widely researched due to their potential therapeutic benefits such as anti-inflammatory, immunomodulatory, neuroprotective, antioxidant, antiemetic activity etc. However, the limitations for THC medicinal use are related to its` bioavailability challenges such as poor water solubility and peroral bioavailability, rapid metabolism, fast initial half‐life (approximately 6 min) and high protein binding (Lucas et al., 2018). These problems might be overcome by encapsulation of THC into drug delivery carriers, such as nanoparticles. The aim of this study was to design and characterize PLGA nanoparticles loaded with THC by emulsion-based preparation method using two different surfactants as stabilizers.
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