Polyetheretherketone (PEEK) implant functionalization with magnetron-sputtered SrTiO3 for regenerative medicine

Q3 Physics and Astronomy

Plasma Medicine Pub Date : 2023-01-01 DOI:10.1615/plasmamed.2023051355

Anjar Anggraini Harumningtyas, Tomoko Ito, Masato Ikuta, Takashi Kaito, Satoshi Hamaguchi

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引用次数: 0

Abstract

Polyetheretherketone (PEEK) is a polymer material widely used for artificial bone implants but known to exhibit a low affinity for bone tissue and lack osteoconductivity and osseointegration. Because strontium (Sr) is known to enhance bone growth, PEEK implants coated with strontium titanate (SrTiO3, STO) is expected to improve the bone growth around them. In this study, STO was deposited on model PEEK implants by magnetron sputtering deposition and its ability to release Sr2+ ions to a surrounding phosphate-buffered saline (PBS) solution was examined. It is found that, in an early stage of the deposition process, STO on a PEEK surface exhibits irregular surface structures with many holes. The amount of Sr stored in the STO film increases with the increasing film thickness but the release rate of Sr2+ ions from the STO film to the surrounding PBS also increases with the film thickness, limiting the duration of effectiveness of the STO-coated PEEK films. It is found, however, that a three-layer titanium (Ti)-STO-Ti film deposited on PEEK allows a steady release of Sr2+ ions to the surrounding PBS for an extended period.

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磁控溅射SrTiO3聚醚醚酮(PEEK)植入体功能化用于再生医学

聚醚醚酮(PEEK)是一种广泛用于人工骨植入物的聚合物材料，但已知其对骨组织的亲和力较低，缺乏骨导电性和骨整合性。由于已知锶(Sr)可以促进骨生长，因此涂覆钛酸锶(SrTiO3, STO)的PEEK植入物有望改善其周围的骨生长。在这项研究中，STO通过磁控溅射沉积在PEEK模型植入物上，并检测其向周围磷酸盐缓冲盐水(PBS)溶液释放Sr2+离子的能力。研究发现，在沉积过程的早期阶段，STO在PEEK表面呈现出不规则的表面结构，具有许多孔洞。STO膜中Sr的储存量随着膜厚的增加而增加，但Sr2+离子从STO膜向周围PBS的释放速率也随着膜厚的增加而增加，从而限制了STO涂层PEEK膜的有效性持续时间。然而，研究发现，沉积在PEEK上的三层钛(Ti)-STO-Ti薄膜允许Sr2+离子在较长时间内稳定释放到周围的PBS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plasma Medicine Physics and Astronomy-Physics and Astronomy (all)

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Technology has always played an important role in medicine and there are many journals today devoted to medical applications of ionizing radiation, lasers, ultrasound, magnetic resonance and others. Plasma technology is a relative newcomer to the field of medicine. Experimental work conducted at several major universities, research centers and companies around the world over the recent decade demonstrates that plasma can be used in variety of medical applications. It is already widely used surgeries and endoscopic procedures. It has been shown to control properties of cellular and tissue matrices, including biocompatibility of various substrates. Non-thermal plasma has been demonstrated to deactivate dangerous pathogens and to stop bleeding without damaging healthy tissue. It can be used to promote wound healing and to treat cancer. Understanding of various mechanisms by which plasma can interact with living systems, including effects of reactive oxygen species, reactive nitrogen species and charges, has begun to emerge recently. The aim of the Plasma Medicine journal will be to provide a forum where the above topics as well as topics closely related to them can be presented and discussed. Existing journals on plasma science and technology are aimed for audiences with primarily engineering and science background. The field of Plasma Medicine, on the other hand, is highly interdisciplinary. Some of prospective readers and contributors of the Plasma Medicine journal are expected to have background in medicine and biology. Others might be more familiar with plasma science. The goal of the proposed Plasma Medicine journal is to bridge the gap between audiences with such different backgrounds, without sacrificing the quality of the papers be their emphasis on medicine, biology or plasma science and technology.