{"title":"Immunological concepts and the combination of cyclophosphamide with 5-aza-2'-deoxycytidine on L1210 in vivo.","authors":"D S Zaharko","doi":"10.3109/08923978509047633","DOIUrl":null,"url":null,"abstract":"<p><p>Experiments were designed to demonstrate the synergism of low dose cyclophosphamide (CY), (15 mg/kg or 45 mg/M2) in combination with 5-aza-2'deoxycytidine (DAC). This dose of CY increased the cytotoxic response to DAC on L1210 tumor in mice by an additional 4 logs of L1210 cell kill or an approximate doubling of the response to DAC alone. These data support the hypothesis that CY at this low dose selectively inhibits suppressor t-cells which normally function to prevent the full cytotoxic potential of DAC from being realized.</p>","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"7 2","pages":"195-202"},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978509047633","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of immunopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/08923978509047633","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Experiments were designed to demonstrate the synergism of low dose cyclophosphamide (CY), (15 mg/kg or 45 mg/M2) in combination with 5-aza-2'deoxycytidine (DAC). This dose of CY increased the cytotoxic response to DAC on L1210 tumor in mice by an additional 4 logs of L1210 cell kill or an approximate doubling of the response to DAC alone. These data support the hypothesis that CY at this low dose selectively inhibits suppressor t-cells which normally function to prevent the full cytotoxic potential of DAC from being realized.
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