"Age-Related Variations of the Brain Mitochondrial Permeability Transition Pore and Complex I in Response to Hypoxia"

Abstract

The opening of the mitochondrial permeability transition pore (mPTP) is thought to be one of the processes leading to cell death during ischemia, while the regulation of opening of the mPTP during development and aging remain obscure. In this study, we compared the effects of in vitro 90 min hypoxia on mPTP sensitivity to Ca2+ mitochondrial respiration, and infarct zone size in 7 day old, 2-3, 8-10 and 24-26 months old rat brains with a particular focus on mitochondrial respiratory chain complex I.