CHOLINESTERASE INHIBITION POTENTIAL OF ENDEMIC SATUREJA SUBSPICATAL.ESSENTIAL OIL AND EXTRACTS

IF 1.3 Q2 AGRICULTURE, MULTIDISCIPLINARY

Acta Technologica Agriculturae Pub Date : 2023-10-01 DOI:10.51558/2232-7568.2023.16.1.7

Mejra Bektašević, Olivera Politeo

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引用次数: 0

Abstract

Medicinal plants are potentialsources of bioactive compounds.One of the medicinal plants used in the traditional medicine of Bosnia and Herzegovina isendemic Satureja subspicataL. In this work, we examined the ability of Satureja subspicataL. essential oil and hot water and methanol extractsto inhibit the enzymes acetylcholinesterase(AChE) and butyrylcholinesterase(BChE) using Ellman’s method.The ability ofSatureja subspicataL. essential oil in concentration of 1 mg/mL and 2 mg/mL to inhibit enzymes was moderate: 72.82%, and 76.89% for AChE, and 51.51%, and 27.15% for BChE, respectively. Analyzed hot water and methanol extractsin concentration of 1 mg/mL showed weak ability of cholinesterase inhibition. Extracts were additionally analyzed regardingtoability to protect proteins from oxidation, during 1 h and 24 h incubation periods. After incubation for 1 hhot water extractshowed a very good protective effect(10.61%), while the methanolic extract showed prooxidative activity. After incubation for 24 h, both extracts showed prooxidative activity.The obtained results show that the examined essential oil and extracts of S. subspicataL. containcompounds withcholinesterase inhibition and antioxidant potential, and thereforecan be useful in treatment of Alzheimer's disease.KEYWORDS:Satureja subspicata, essential oil, extracts, cholinesterase inhibition, protein oxidation

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地方性血吸虫棘下胆碱酯酶抑制潜力。精油及提取物

药用植物是生物活性化合物的潜在来源。波斯尼亚和黑塞哥维那传统医药中使用的药用植物之一是地方性的Satureja subspicataL。在这项工作中，我们检查了Satureja亚特异性atal的能力。采用Ellman的方法，用精油、热水和甲醇提取物抑制乙酰胆碱酯酶(AChE)和丁基胆碱酯酶(BChE)。satureja subspital的能力。浓度为1 mg/mL和2 mg/mL的精油对酶的抑制作用适中，对AChE的抑制作用分别为72.82%和76.89%，对BChE的抑制作用分别为51.51%和27.15%。热水和甲醇提取物浓度为1 mg/mL时，胆碱酯酶抑制能力较弱。在1小时和24小时的孵育期间，还分析了提取物保护蛋白质免受氧化的能力。热水浸提液经1次培养后显示出很好的保护作用(10.61%)，而甲醇浸提液具有促氧化活性。孵育24 h后，两种提取物均表现出抗氧化活性。结果表明，所检测的香参精油和提取物具有一定的化学活性。含有胆碱酯酶抑制和抗氧化潜力的化合物，因此可用于治疗阿尔茨海默病。关键词:木香，精油，提取物，胆碱酯酶抑制，蛋白质氧化

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来源期刊

Acta Technologica Agriculturae AGRICULTURE, MULTIDISCIPLINARY-

CiteScore

2.50

自引率

28.60%

发文量

审稿时长

18 weeks

期刊介绍： Acta Technologica Agriculturae is an international scientific double-blind peer reviewed journal focused on agricultural engineering. The journal is multidisciplinary and publishes original research and review papers in engineering, agricultural and biological sciences, and materials science. Aims and Scope Areas of interest include but are not limited to: agricultural and biosystems engineering; machines and mechanization of agricultural production; information and electrical technologies; agro-product and food processing engineering; physical, chemical and biological changes in the soil caused by tillage and field traffic, soil working machinery and terramechanics; renewable energy sources and bioenergy; rural buildings; related issues from applied physics and chemistry, ecology, economy and energy.