Antinociceptive Effect of Methanol Extract of <i>Diospyros malabarica</i> (Desr.) Kostel Leaves in Mice

Md. Azim Uddin, Ambia Khatun, Md. Abdul Mannan
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Abstract

Background: Diospyros malabarica (Desr.) Kostel, a small to medium-sized tree in the Ebenaceae family, is known as “Deshi Gab” in Bangladesh. Fever, diabetes, snake bite, diarrhea, biliousness, and ulcer ailments are all treated with the herb. This study’s goal was to examine in mouse models the antinociceptive properties of methanol extract of Diospyros malabarica leaves (MEDM). Methods: For the purpose of determining the antinociceptive activity in mice, five distinct pain models including hot plate, tail immersion, acetic acid-induced writhing, formalin and glutamate-induced nociception tests were used. The conventional medications were morphine sulphate (5 mg/kg, intraperitoneally) and diclofenac sodium (10 mg/kg, intraperitoneally). While the control group was expecting deionized water, MEDM was given orally at dosages of 200, 400, and 600 mg/kg (0.1 mL/mouse, orally). Results: According to the current research, MEDM strongly reflected the antinociceptive activity of all mouse models of chemical and heat-induced pain (*p Conclusions: It is evident that the plant extract has exceptional analgesic properties. To determine the precise processes behind antinociceptive effect and to identify the substances that produce this activity, more research is required. The study’s findings also support the long-standing use of MEDM in painful conditions.
甲醇提取物</i>;(较)。老鼠体内的Kostel叶子
背景:malabarica Diospyros (Desr.)Kostel是一种小型到中型的Ebenaceae科树木,在孟加拉国被称为“Deshi Gab”。发烧,糖尿病,蛇咬伤,腹泻,胆汁和溃疡疾病都可以用这种草药治疗。本研究的目的是在小鼠模型中研究刺蒺藜叶甲醇提取物(MEDM)的抗伤性。方法:采用热板、尾浸、醋酸扭体、福尔马林和谷氨酸诱导的五种不同疼痛模型,测定小鼠的抗伤害感受活性。常规药物为硫酸吗啡(5 mg/kg,腹腔注射)和双氯芬酸钠(10 mg/kg,腹腔注射)。对照组给予去离子水,分别以200、400、600 mg/kg (0.1 mL/只,口服)的剂量给予MEDM。结果:根据目前的研究,MEDM强烈反映了化学和热致疼痛小鼠模型的抗镇痛活性(*p)。结论:很明显,该植物提取物具有特殊的镇痛特性。为了确定抗痛觉效应背后的精确过程,并确定产生这种活性的物质,还需要进行更多的研究。研究结果也支持长期使用MEDM治疗疼痛。
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