Data-driven Adaptive Testing Resource Allocation Strategies for Real-time Monitoring of Infectious Diseases

Abstract

AbstractSince 2002 with the SARS outbreak, infectious diseases, including the ongoing COVID-19 pandemic, have continued to be a major global public health threat. It is critical to develop effective data science methods to quickly detect disease outbreaks and contain their rapid globalized spread. However, in practice, limited testing availability, and thus insufficient testing data poses significant challenges in effective analysis and real-time monitoring of infectious diseases, especially during early stages of a novel disease outbreak. To tackle these challenges, this article proposes adaptive testing resource allocation strategies integrated with a physics-informed model to dynamically allocate limited testing resources across different communities. The physics-informed model accounts for transmission dynamics and health disparities, enabling effective health risk assessment despite limited data. By integrating nonstationary Multi-Armed Bandit (MAB) techniques that strike superior balance between exploring the communities with high uncertain risks and exploiting those with high risk levels, the proposed methodology facilitates test allocation to collect high-quality testing data for early outbreak detection. Theoretical analysis is carried out to evaluate the performance of the proposed allocation strategies, ensuring either sublinear or linear dynamic pseudo-regret under regularity assumptions. A comprehensive simulation study is conducted under three transmission scenarios to thoroughly evaluate the proposed methodology.Keywords: data-drivenhealth disparityinfectious diseasesMulti-Armed Bandit (MAB)real-time monitoringresource allocationtransmission dynamicsDisclaimerAs a service to authors and researchers we are providing this version of an accepted manuscript (AM). Copyediting, typesetting, and review of the resulting proofs will be undertaken on this manuscript before final publication of the Version of Record (VoR). During production and pre-press, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal relate to these versions also.