SESN1, as a potential target for postoperative cognitive dysfunction, attenuates sevoflurane-induced neuronal cell damage in the hippocampus

IF 1 4区医学 Q3 EMERGENCY MEDICINE

Signa Vitae Pub Date : 2023-01-01 DOI:10.22514/sv.2023.107

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引用次数: 0

Abstract

Postoperative cognitive dysfunction (POCD) is a devastating complication with long-term consequences, and new therapeutic targets and drugs are still needed for the treatment of POCD. Sestrin are a family of stress-inducing proteins that regulate cellular metabolic networks. However, the possible effects of Sestrin on POCD were still unclear. This study aimed to investigate the effects of Sestrin 1 (SESN1) in postoperative cognitive dysfunction (POCD) cell model and reveal its mechanism. We constructed an in vitro model of POCD by treating primary rat hippocampal neurons with sevoflurane. Herein, we noticed SESN1 enhanced cell viability induced by sevoflurane. Further, SESN1 improved sevoflurane-induced cell inflammation. We further found that SESN1 improved sevoflurane induced reactive oxygen species (ROS) production and inhibited apoptosis. Mechanically, SESN1 restrained NOD-like receptor thermal protein domain 3 (NLRP3) inflammasome activation and therefore suppressed POCD. In conclusion, SESN1, as a potential target for postoperative cognitive dysfunction, attenuates sevoflurane-induced neuronal cell damage in the hippocampus. These findings will provide guidance for the mechanism study of POCD and future drug development for treatment of POCD.

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SESN1作为术后认知功能障碍的潜在靶点，可减轻七氟醚诱导的海马神经元细胞损伤

术后认知功能障碍(POCD)是一种具有长期后果的破坏性并发症，治疗POCD仍需要新的治疗靶点和药物。Sestrin是调节细胞代谢网络的应激诱导蛋白家族。然而，Sestrin对POCD的可能影响尚不清楚。本研究旨在探讨Sestrin 1 (SESN1)在术后认知功能障碍(POCD)细胞模型中的作用及其机制。用七氟醚处理大鼠海马原代神经元，建立POCD体外模型。在这里，我们注意到SESN1增强了七氟醚诱导的细胞活力。此外，SESN1改善了七氟醚诱导的细胞炎症。我们进一步发现SESN1改善了七氟醚诱导的活性氧(ROS)的产生，并抑制了细胞凋亡。机制上，SESN1抑制nod样受体热蛋白结构域3 (NLRP3)炎性体激活，从而抑制POCD。综上所述，SESN1作为术后认知功能障碍的潜在靶点，可减轻七氟醚诱导的海马神经元细胞损伤。这些发现将为POCD的机制研究和未来治疗POCD的药物开发提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Signa Vitae 医学-急救医学

CiteScore

1.30

自引率

9.10%

发文量

审稿时长

3 months

期刊介绍： Signa Vitae is a completely open-access，peer-reviewed journal dedicate to deliver the leading edge research in anaesthesia, intensive care and emergency medicine to publics. The journal’s intention is to be practice-oriented, so we focus on the clinical practice and fundamental understanding of adult, pediatric and neonatal intensive care, as well as anesthesia and emergency medicine. Although Signa Vitae is primarily a clinical journal, we welcome submissions of basic science papers if the authors can demonstrate their clinical relevance. The Signa Vitae journal encourages scientists and academicians all around the world to share their original writings in the form of original research, review, mini-review, systematic review, short communication, case report, letter to the editor, commentary, rapid report, news and views, as well as meeting report. Full texts of all published articles, can be downloaded for free from our web site.