None MUHAMMAD YOUSIF JAKHRANI, None ALI MUJTABA SHAH, None MUHAMMAD FAROOQUE HASSAN, None AYESHA LAGHARI, None HABIBULLAH JANYARO, None AZHAR HYDER KAZI, None KHUSHBOO SOOMRO, None ANEES AHMED BURIRO
{"title":"Comperative Study on Anesthetic Effect of Xylazine-Ketamine And Diazepam-Ketamine In Rabbit Model","authors":"None MUHAMMAD YOUSIF JAKHRANI, None ALI MUJTABA SHAH, None MUHAMMAD FAROOQUE HASSAN, None AYESHA LAGHARI, None HABIBULLAH JANYARO, None AZHAR HYDER KAZI, None KHUSHBOO SOOMRO, None ANEES AHMED BURIRO","doi":"10.57038/usjas.v7i03.6506","DOIUrl":null,"url":null,"abstract":"This study was conducted to investigate the anesthetic effects of Xylazine-ketamine and Diazepam-ketamine in rabbits. Twelve adult white New-Zealand rabbits weighing 1.3+0.2 kg, were divided into two groups. A (Xylazine 5mg/kg – ketamine 35mg/kg) and B (Diazepam 5mg/kg – ketamine 35mg/kg). However, the following parameters were observed: analgesic effects (onset and duration) and clinical-parameters (means of heart-rates/BPM, respiratory-rates/BPM and rectal temperature. The onset was significantly p<0.05 increased, and the duration was significantly p>0.05 decreased in A. The heart-rate and the respiratory-rate was significantly p<0.01 decreased in A. But the rectal temperature decreased non-significantly p>0.05 in both groups. General observations: in Group A, urination, nasal-discharge, salivation and lacrimation were present, in Group B, defecation, corneal-reflex and pedal-reflex were observed at their peak. It was concluded that the xylazine-ketamine is used for clinical/surgical procedures, while diazepam-ketamine may further be investigated by using other analgesics with this combination.","PeriodicalId":265691,"journal":{"name":"University of Sindh Journal of Animal Sciences (USJAS)","volume":"7 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"University of Sindh Journal of Animal Sciences (USJAS)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.57038/usjas.v7i03.6506","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
This study was conducted to investigate the anesthetic effects of Xylazine-ketamine and Diazepam-ketamine in rabbits. Twelve adult white New-Zealand rabbits weighing 1.3+0.2 kg, were divided into two groups. A (Xylazine 5mg/kg – ketamine 35mg/kg) and B (Diazepam 5mg/kg – ketamine 35mg/kg). However, the following parameters were observed: analgesic effects (onset and duration) and clinical-parameters (means of heart-rates/BPM, respiratory-rates/BPM and rectal temperature. The onset was significantly p<0.05 increased, and the duration was significantly p>0.05 decreased in A. The heart-rate and the respiratory-rate was significantly p<0.01 decreased in A. But the rectal temperature decreased non-significantly p>0.05 in both groups. General observations: in Group A, urination, nasal-discharge, salivation and lacrimation were present, in Group B, defecation, corneal-reflex and pedal-reflex were observed at their peak. It was concluded that the xylazine-ketamine is used for clinical/surgical procedures, while diazepam-ketamine may further be investigated by using other analgesics with this combination.