Comperative Study on Anesthetic Effect of Xylazine-Ketamine And Diazepam-Ketamine In Rabbit Model

None MUHAMMAD YOUSIF JAKHRANI, None ALI MUJTABA SHAH, None MUHAMMAD FAROOQUE HASSAN, None AYESHA LAGHARI, None HABIBULLAH JANYARO, None AZHAR HYDER KAZI, None KHUSHBOO SOOMRO, None ANEES AHMED BURIRO
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Abstract

This study was conducted to investigate the anesthetic effects of Xylazine-ketamine and Diazepam-ketamine in rabbits. Twelve adult white New-Zealand rabbits weighing 1.3+0.2 kg, were divided into two groups. A (Xylazine 5mg/kg – ketamine 35mg/kg) and B (Diazepam 5mg/kg – ketamine 35mg/kg). However, the following parameters were observed: analgesic effects (onset and duration) and clinical-parameters (means of heart-rates/BPM, respiratory-rates/BPM and rectal temperature. The onset was significantly p<0.05 increased, and the duration was significantly p>0.05 decreased in A. The heart-rate and the respiratory-rate was significantly p<0.01 decreased in A. But the rectal temperature decreased non-significantly p>0.05 in both groups. General observations: in Group A, urination, nasal-discharge, salivation and lacrimation were present, in Group B, defecation, corneal-reflex and pedal-reflex were observed at their peak. It was concluded that the xylazine-ketamine is used for clinical/surgical procedures, while diazepam-ketamine may further be investigated by using other analgesics with this combination.
噻嗪-氯胺酮与安定-氯胺酮对兔模型麻醉效果的比较研究
研究了氯胺酮和氯胺酮对家兔的麻醉作用。选取体重1.3+0.2 kg的成年新西兰白兔12只,随机分为两组。A(噻嗪5mg/kg -氯胺酮35mg/kg)和B(地西泮5mg/kg -氯胺酮35mg/kg)。然而,观察以下参数:镇痛效果(开始和持续时间)和临床参数(心率/BPM,呼吸频率/BPM和直肠温度的平均值)。a组发病时间显著增高(p < 0.05),持续时间显著增高(p < 0.05), a组心率和呼吸频率显著增高(p < 0.01),但两组直肠温度均无显著增高(p < 0.05)。一般观察:A组有排尿、鼻分泌物、流涎、流泪,B组有排便、角膜反射、足部反射高峰。结论是,氯胺酮用于临床/外科手术,而地西泮-氯胺酮可进一步研究使用其他镇痛药与此组合。
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