Deciphering the Role of Various Signaling Pathways in the Pathophysiology of Depression

Q3 Medicine

Current Signal Transduction Therapy Pub Date : 2023-10-05 DOI:10.2174/0115743624255521230920070219

Etash Vashisht, Vishal Vats, Ravinder Verma, Jatin Parashar, Vandana Garg, Rohit Dutt, Vineet Mittal, Govind Singh, Deepak Kaushik

{"title":"Deciphering the Role of Various Signaling Pathways in the Pathophysiology of Depression","authors":"Etash Vashisht, Vishal Vats, Ravinder Verma, Jatin Parashar, Vandana Garg, Rohit Dutt, Vineet Mittal, Govind Singh, Deepak Kaushik","doi":"10.2174/0115743624255521230920070219","DOIUrl":null,"url":null,"abstract":"Background: Depression is one of the leading causes of disability around the globe. In the early years of depression, it is hypothesized that neurotransmitters have a major or dominant role in depression pathophysiology. The roles of different parts of the brain and neurotransmitters have emerged at different intervals of time, and various hypotheses beyond monoamines have arisen. In this review, numerous theories that have been proposed in the last 60 years are covered based on the literature. Methodology: This review was prepared with literature and data presented from different databases including PubMed, Frontier in Pharmacology, Elsevier, Journal of Depression and Anxiety, etc. Results: The different hypotheses of depression have been presented in different eras. Each hypothesis of depression tries to explore different aspects of depression, which shifts the pathogenesis of depression approaches towards bio-molecule and genetic roles. Conclusion: The pathophysiology of depression is very complex. None of the hypotheses alone can explain the pathophysiology of depression. All of these hypotheses are interconnected with each other. Through these hypotheses, it can be concluded that neuro-inflammation can be the base of depression and by reducing this factor we can overcome this problem","PeriodicalId":10868,"journal":{"name":"Current Signal Transduction Therapy","volume":"4 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Signal Transduction Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0115743624255521230920070219","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Depression is one of the leading causes of disability around the globe. In the early years of depression, it is hypothesized that neurotransmitters have a major or dominant role in depression pathophysiology. The roles of different parts of the brain and neurotransmitters have emerged at different intervals of time, and various hypotheses beyond monoamines have arisen. In this review, numerous theories that have been proposed in the last 60 years are covered based on the literature. Methodology: This review was prepared with literature and data presented from different databases including PubMed, Frontier in Pharmacology, Elsevier, Journal of Depression and Anxiety, etc. Results: The different hypotheses of depression have been presented in different eras. Each hypothesis of depression tries to explore different aspects of depression, which shifts the pathogenesis of depression approaches towards bio-molecule and genetic roles. Conclusion: The pathophysiology of depression is very complex. None of the hypotheses alone can explain the pathophysiology of depression. All of these hypotheses are interconnected with each other. Through these hypotheses, it can be concluded that neuro-inflammation can be the base of depression and by reducing this factor we can overcome this problem

查看原文本刊更多论文

解读多种信号通路在抑郁症病理生理中的作用

背景:抑郁症是全球范围内致残的主要原因之一。在抑郁症的早期，人们假设神经递质在抑郁症的病理生理中起主要或主导作用。大脑的不同部分和神经递质的作用在不同的时间间隔出现，除了单胺之外的各种假设也出现了。在这篇综述中，在文献的基础上，涵盖了过去60年来提出的许多理论。方法学:本综述采用来自PubMed、Frontier in Pharmacology、Elsevier、Journal of Depression and Anxiety等不同数据库的文献和数据。结果:不同时期出现了不同的抑郁假说。每一种假说都试图探索抑郁症的不同方面，从而将抑郁症的发病机制转向生物分子和遗传作用。结论:抑郁症的病理生理十分复杂。这些假说都不能单独解释抑郁症的病理生理学。所有这些假设都是相互联系的。通过这些假设，可以得出结论，神经炎症可能是抑郁症的基础，通过减少这一因素，我们可以克服这一问题

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Signal Transduction Therapy 医学-药学

CiteScore

1.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： In recent years a breakthrough has occurred in our understanding of the molecular pathomechanisms of human diseases whereby most of our diseases are related to intra and intercellular communication disorders. The concept of signal transduction therapy has got into the front line of modern drug research, and a multidisciplinary approach is being used to identify and treat signaling disorders. The journal publishes timely in-depth reviews, research article and drug clinical trial studies in the field of signal transduction therapy. Thematic issues are also published to cover selected areas of signal transduction therapy. Coverage of the field includes genomics, proteomics, medicinal chemistry and the relevant diseases involved in signaling e.g. cancer, neurodegenerative and inflammatory diseases. Current Signal Transduction Therapy is an essential journal for all involved in drug design and discovery.