Intracranial Cavernous Malformation with Concomitant Isolated Cerebral Mucormycosis Infection: A Case Report

Pratishtha Sengar, Nityanand Pandey, Vikas Kailashiya, Varun Kumar Singh
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Abstract

Abstract Cerebral cavernous malformation is an angiographically occult, well-circumscribed, benign hamartoma consisting of thin-walled sinusoidal vascular channels. Intracranial mucormycosis represents one of the most severe manifestations of mucor infection. We, hereby, report a case of cavernous malformation made rarer with concomitant mucormycosis. A 22-year-old female presented with left-sided facial seizures since age of 7 years and headache for the past 3 years. Magnetic resonance imaging brain revealed a right posterior frontal lobe cavernous malformation. Right frontal craniotomy with excision of cavernoma was done. Gross examination showed a solid cystic mass with multiple mulberry protrusions. Histopathological examination revealed features of cavernous malformation with evidence of mucormycosis. A final diagnosis of cavernous malformation with mucormycosis was rendered and microbiological studies were advised. To the best of our knowledge, this is the first case report of a cerebral cavernous malformation with mucormycosis in an immunocompetent patient without any risk factor.
颅内海绵体畸形伴孤立性脑毛霉菌病感染1例
摘要:脑海绵状血管瘤是一种由薄壁正弦血管通道组成的血管造影隐匿、边界明确的良性错构瘤。颅内毛霉病是毛霉感染最严重的表现之一。在此,我们报告一例海绵体畸形与伴随毛霉菌病的罕见病例。22岁女性,7岁以来左侧面部癫痫发作,过去3年头痛。脑磁共振成像显示右侧额叶后海绵状畸形。右额叶开颅切除海绵状瘤。大体检查显示实性囊性肿块伴多发桑葚突。组织病理学检查显示海绵状畸形的特征,并有毛霉病的证据。最终诊断为海绵状畸形伴毛霉菌病,并建议进行微生物学检查。据我们所知,这是第一例无任何危险因素的免疫功能正常的脑海绵体畸形伴毛霉菌病的病例报告。
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