Implications of Multimerin-1 (MMRN-1) expression in adult de novo acute myeloid leukemia: a preliminary study in Delta Egypt

Egyptian Journal of Basic and Applied Sciences Pub Date : 2023-09-27 DOI:10.1080/2314808x.2023.2252233

Nadia El Menshawy, Mohamed S. El-Goneimy, Hyam Fathi, Maha Saif, Heba Hashem

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引用次数: 0

Abstract

Adult acute myeloid leukemia (AML) is challengeable disease with poor heterogeneous outcome. Refining risk stratification is important for decision making and tailoring of therapy, multimerin-1(MMRN1) has been identified as a differentially expressed gene (DEG) in various cancers and it has been proposed as a possible cancer biomarker so, we aim to address prognostic value of Multimerin-1 in adult AML. This study was conducted on 240 AML, 40 healthy control, Taq man gene expression by RT PCR. Higher expression of Multimerin-1 was significant associated with failure of complete remission, relapse, short survival, highly significant association with minimal residual disease (MRD) positivity, molecular FLT3 (p 0.004, p.008) unfavorable cytogenetic (0.013). Cut off > 2.38 shows significantly short Overall Survival (OS), Disease-Free Survival (DFS). Finally, it could be independent poor risk for short survival; relapse thus may help in refine AML risk-stratification and tailoring therapy toward personalized medicine.

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多聚蛋白-1 (MMRN-1)表达在成人新生急性髓性白血病中的意义:埃及三角洲地区的初步研究

成人急性髓性白血病(AML)是一种异质性较差的疾病。细化风险分层对于决策和治疗的定制非常重要，多聚蛋白-1(MMRN1)已被确定为多种癌症中的差异表达基因(DEG)，并已被提出作为一种可能的癌症生物标志物，因此，我们的目标是解决多聚蛋白-1在成人AML中的预后价值。本研究采用RT - PCR方法对240例AML患者和40例健康对照者进行Taq man基因的表达。多聚蛋白-1的高表达与完全缓解失败、复发、短生存期显著相关，与最小残留病(MRD)阳性、分子FLT3 (p 0.004, p 0.008)不利的细胞遗传学(p 0.013)高度显著相关。Cut off > 2.38表示总生存期(OS)、无病生存期(DFS)明显缩短。最后，它可能是短期生存的独立低风险;因此，复发可能有助于改进AML风险分层和个性化治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Egyptian Journal of Basic and Applied Sciences

CiteScore

2.20

自引率

0.00%

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