New Hybrid Compounds from Imidazole and 1,2,3-Triazole: efficient Synthesis of Highly Substituted Imidazoles and Construction of Their Novel Hybrid Compounds by Copper-Catalyzed Click Reaction

Abstract

New hybrid compounds were successfully prepared from highly substituted imidazoles and 1,2,3-triazoles using copper-catalyzed click reactions. Also, an efficient method described for the synthesis of tri- and tetrasubstituted imidazoles in the presence of ZnCl₂/urea as an efficient catalyst by multi-component reaction under solvent-free conditions. The advantages of this one-pot methodology are experimental simplicity, easy work-up, and afford desired products with high to excellent yields.