Circular RNA Translation in Cardiovascular Diseases

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-03-01 DOI:10.2174/1389202924666230911121358

Lijun Wang, Xinxin Cui, Fei Jiang, Yuxue Hu, Wensi Wan, Guoping Li, Yanjuan Lin, Junjie Xiao

引用次数: 0

Abstract

Abstract: Circular RNAs (circRNAs) are a class of endogenous functional RNA generated by backsplicing. Recently, circRNAs have been found to have certain coding potential. Proteins/peptides translated from circRNAs play essential roles in various diseases. Here, we briefly summarize the basic knowledge and technologies that are usually applied to study circRNA translation. Then, we focus on the research progress of circRNA translation in cardiovascular diseases and discuss the perspective and future direction of translatable circRNA study in cardiovascular diseases.

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心血管疾病中的环状RNA翻译

摘要:环状RNA (Circular RNA, circRNAs)是一类通过反剪接产生的内源性功能性RNA。最近，人们发现环状rna具有一定的编码潜能。由环状rna翻译的蛋白质/肽在多种疾病中发挥重要作用。在这里，我们简要总结了circRNA翻译研究中常用的基本知识和技术。然后，我们重点关注circRNA翻译在心血管疾病中的研究进展，并讨论可翻译circRNA在心血管疾病中的研究前景和未来方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.