Insulin Resistance Associated with Impaired Fasting Glycaemia in Anti-Retroviral Therapy Patients

Abstract

Background: Insulin resistance was associated with type-2 diabetes mellitus regardless of HIV status. However, an association of insulin resistance in prediabetes with HIV-infected subjects undergoing anti-retroviral therapy (ART) has been reported in very few studies. Methods: Serum insulin and insulin resistance (HOMA-IR) were measured in ART patients with impaired fasting glycemia (IFG) and those with normal glucose tolerance (NGT) along with other biochemical parameters. Results: There was increased insulin resistance in the ART IFG group when compared to their ART NGT counterparts. There was a positive correlation of HOMA-IR with serum creatinine, triglycerides, and ALT levels. However, serum HDL showed a negative correlation with HOMA-IR. Conclusion: Present study showed that there is association of insulin resistance in IFG associated with HIV-infected subjects on ART. Hence, monitoring the insulin resistance in ART patients may help in early prevention of type 2 diabetes mellitus. Keywords: Human Immunodeficiency Virus, anti-retroviral therapy, impaired fasting glycemia, serum Insulin, HOMA-IR