Analysis of trends and necessity of extemporal compounding of medicinal forms in pharmacies during wartime and the COVID-19 pandemic in Ukraine

Abstract

The need to saving of the pharmacies are preparing extemporaneous dosage forms (DF) is substantiated, and their effectiveness in the conditions of the coronavirus pandemic, martial law is shown. The purpose of work was to conduct an analysis of the dynamics of the pharmacy number that manufacture EDF on the example of the Lviv region, the city of Lviv during 30 years, in order to determine trends. It was to study the list of DFs that were extemporaneously compounded. The list of DFs was analyzed, with an emphasis on the list of disinfectant solutions for sanitizing hands during the COVID-19 pandemic and wartime. The analysis objects were documents, order books of pharmacies with production departments during 30 years of activity. The list of pharmaceuticals from 14 pharmacies that have valid licenses and actually carry out extemporaneous production in the city of Lviv, the Lviv region was studied. Research methods: historical, bibliographic, documentary, content analysis, systematization and generalization. We have selected a set of 11 dosage forms, which were most often compounded during the coronavirus pandemic and martial law during 2020-2023, these prescriptions can be recommended for implementation in the work of compounding departments of private pharmacies. It was found that most industrial disinfectant solutions contain 60% isopropyl alcohol or 70%‒75% ethyl alcohol, so these solutions do not meet WHO recommendations for disinfection during a pandemic COVID-19. It was established that the costs of disinfectant solutions per one litre were higher by 44.4% compared to one litre of extemporaneous production disinfectants, which has significant economic benefits for the rational use of budget funds. It was substantiated that the urgent task of harmonizing with the legislation of the European Union regarding the work of pharmacies that have extemporaneous production requires the introduction of changes to the Resolution of the CMU dated 30.11.2016 N 929 on Licensing conditions for conducting business activities in the production of medicinal products, wholesale and retail trade medicinal products, on the mandatory extemporaneous production of medicinal forms in each pharmacy, regardless of the form of ownership. It was established that 71.4% of extemporaneous pharmacies are communally owned, when chain pharmacies do not perform such a function at all, therefore it is necessary to harmonize with EU requirements for the presence of compounding departments in each pharmacy with good conditions and personnel for production. The need for a hospital pharmacy with appropriate staff in each hospital for the preparation of sterile and non-sterile medical forms in Ukraine, and to ensure the practice of students and the internship of pharmacists is substantiated.