Effect of Plasmodium Infections on CD4 Cells, Neutrophil and Lymphocytes

Emmanuel Chike Amadi, Chukwuemeka Chijoke Nwangwu, Emmanuel A. Eze, Sylvia Ijeoma Adaugo Anyaehie
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Abstract

Knowledge of malaria-immunity is essential for understanding the pathology, treatment & vaccine production. So, changes in CD4 in malaria patients were studied at a teaching hospital in Enugu, Nigeria. 45 patients on doctor’s provisional diagnosis of malaria were examined for Plasmodium infections and the degree of parasitaemia (0/+/ ++/ & +++). Positive/(+) and negative/(0) samples were thereafter counted for CD4 using Flow Cytometry. CD4 cell count of Plasmodium-negative specimens were within reference ranges (RR): (464-1308); mean value: 835. Fifteen (+) parasitaemia showed lower ranges of CD4 count (502-1282); mean: 678; with immune falls in one (427). 9/12 (++) parasitaemia showed crash in CD4 counts, range: 301- 415; mean: 399. Seven (+++) parasitaemia showed crashes in CD4 counts, range: 160-357; mean: 225. As parasitaemia rises, neutrophils, Total WBC and lymphocyte significantly rise in numeric. Malaria causes immunosuppression; unlike prevailing reports, should accelerate complications in immunodeficients-patients, Haemolytic-anaemia results only from chronic cases. CD4 counts should be a paradigm in malaria investigation.
疟原虫感染对CD4细胞、中性粒细胞和淋巴细胞的影响
疟疾免疫知识对于了解疟疾的病理、治疗和治疗至关重要。疫苗生产。因此,我们在尼日利亚埃努古的一家教学医院研究了疟疾患者CD4的变化,对45例医生临时诊断为疟疾的患者进行了疟原虫感染和寄生虫血症程度的检查(0/+/ ++/ &+ + +)。然后用流式细胞术对阳性/(+)和阴性/(0)样品进行CD4计数。疟原虫阴性标本CD4细胞计数在参考范围内(RR):(464 ~ 1308);平均值:835。15例(+)寄生虫血症CD4计数较低(502 ~ 1282);意思是:678;与免疫落在一起(427)。9/12(++)寄生虫血症CD4计数崩溃,范围:301- 415;意思是:399。7个(+++)寄生虫血症显示CD4计数崩溃,范围:160-357;意思是:225。随着寄生虫病的增加,中性粒细胞、白细胞总数和淋巴细胞数量显著增加。疟疾引起免疫抑制;与主流报道不同的是,溶血性贫血只发生于慢性病例,它会加速免疫缺陷患者的并发症。CD4计数应成为疟疾调查的一个范例。
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