Protein Carbamylation in Neurodegeneration and other age-related disorders

IF 1.5 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Indian journal of biochemistry & biophysics Pub Date : 2023-01-01 DOI:10.56042/ijbb.v60i9.4103

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引用次数: 0

Abstract

Ageing is a complex process that is greatly influenced by environmental and genetic factors. Ageing at the cellular and molecular level is characterized by the accumulation of post-translationally modified proteins that are derogative to cells, termed Degenerative protein modification (DPM). A particular class of DPM, occurring under the impact of urea, termed brain ureido degenerative post-translational modifications (uDPM) has also been implicated in the molecular pathogenesis of Alzheimer's disease and related neurodegenerative disorders. These modifications can disrupt normal protein functions by altering their conformation, enzymatic activities, receptor recognitions, and physiological capabilities. Carbamylation is an age-related uDPM that results from the non-enzymatic modification of amino groups of ε-amino groups on lysine in proteins. The significance of carbamylation in some age-related disorders such as cataracts, rheumatoid arthritis,and cardiovascular diseases is well documented.However, the role of carbamylation in the pathogenesis of various neurodegenerative disorders, which are also age-dependent, has not been explored much. The aim of the current article is a retrospection of carbamylation, its effect on proteins, and its implications in ageing and neurodegenerative diseases. Carbamylation is one such age-related uDPM, which results from the non-enzymatic modification of amino groups of ε-amino groups on lysines or N-terminal amino groups present in proteins or peptides by isocyanate. The significance of carbamylation in some age-related disorders such as cataracts, rheumatoid arthritis, and cardiovascular diseases is well documented. However, the role of carbamylation in the pathogenesis of various neurodegenerative disorders, which are also age-dependent, has not been explored much. This mini-review will focus on the relationship between carbamylation and neurodegenerative disorders and provide an overview of the process of carbamylation, its contribution towards molecular ageing of protein, and the involvement of carbamylation in neurodegeneration and related diseases associated with ageing.

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蛋白质氨基甲酰化在神经退行性疾病和其他与年龄相关的疾病

衰老是一个复杂的过程，受环境和遗传因素的影响很大。在细胞和分子水平上，衰老的特征是翻译后修饰蛋白质的积累，这些蛋白质对细胞有害，称为退行性蛋白质修饰(DPM)。在尿素作用下发生的一类特殊的DPM，被称为脑尿素退行性翻译后修饰(uDPM)，也与阿尔茨海默病和相关神经退行性疾病的分子发病机制有关。这些修饰可以通过改变蛋白质的构象、酶活性、受体识别和生理能力来破坏正常的蛋白质功能。氨甲酰化是一种与年龄相关的uDPM，它是由蛋白质赖氨酸上ε-氨基的氨基非酶修饰引起的。氨甲酰化在一些与年龄相关的疾病，如白内障、风湿性关节炎和心血管疾病中的意义已被充分证明。然而，氨甲酰化在各种神经退行性疾病的发病机制中的作用，也与年龄有关，尚未得到很多探讨。本文的目的是回顾氨甲酰化，它对蛋白质的影响，以及它在衰老和神经退行性疾病中的意义。氨基甲酰化就是这样一种与年龄相关的uDPM，它是由异氰酸酯对赖氨酸上的ε-氨基或蛋白质或肽中的n端氨基进行非酶修饰而产生的。氨甲酰化在一些与年龄相关的疾病，如白内障、风湿性关节炎和心血管疾病中的意义已被充分证明。然而，氨甲酰化在各种神经退行性疾病的发病机制中的作用，也与年龄有关，尚未得到很多探讨。这篇综述将重点关注氨甲酰化与神经退行性疾病之间的关系，并概述氨甲酰化的过程，它对蛋白质分子老化的贡献，以及氨甲酰化在神经退行性疾病和与衰老相关的相关疾病中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian journal of biochemistry & biophysics 生物-生化与分子生物学

CiteScore

2.90

自引率

50.00%

发文量

审稿时长

3 months

期刊介绍： Started in 1964, this journal publishes original research articles in the following areas: structure-function relationships of biomolecules; biomolecular recognition, protein-protein and protein-DNA interactions; gene-cloning, genetic engineering, genome analysis, gene targeting, gene expression, vectors, gene therapy; drug targeting, drug design; molecular basis of genetic diseases; conformational studies, computer simulation, novel DNA structures and their biological implications, protein folding; enzymes structure, catalytic mechanisms, regulation; membrane biochemistry, transport, ion channels, signal transduction, cell-cell communication, glycobiology; receptors, antigen-antibody binding, neurochemistry, ageing, apoptosis, cell cycle control; hormones, growth factors; oncogenes, host-virus interactions, viral assembly and structure; intermediary metabolism, molecular basis of disease processes, vitamins, coenzymes, carrier proteins, toxicology; plant and microbial biochemistry; surface forces, micelles and microemulsions, colloids, electrical phenomena, etc. in biological systems. Solicited peer reviewed articles on contemporary Themes and Methods in Biochemistry and Biophysics form an important feature of IJBB. Review articles on a current topic in the above fields are also considered. They must dwell more on research work done during the last couple of years in the field and authors should integrate their own work with that of others with acumen and authenticity, mere compilation of references by a third party is discouraged. While IJBB strongly promotes innovative novel research works for publication as full length papers, it also considers research data emanating from limited objectives, and extension of ongoing experimental works as ‘Notes’. IJBB follows “Double Blind Review process” where author names, affiliations and other correspondence details are removed to ensure fare evaluation. At the same time, reviewer names are not disclosed to authors.