Coagulation Profile Alterations in Dogs Co-Infected with Visceral Leishmaniasis and Monocytic Ehrlichiosis

IF 0.8 4区农林科学 Q3 VETERINARY SCIENCES

Kafkas Universitesi Veteriner Fakultesi Dergisi Pub Date : 2023-01-01 DOI:10.9775/kvfd.2023.29887

Canberk BALIKÇI, Erdem GÜLERSOY, Adem ŞAHAN, İsmail GÜNAL

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Abstract

Canine Visceral Leishmaniasis (CVL) and Canine Monocytic Ehrlichiosis (CME) are zoonotic diseases that cause coagulation disorders, abnormalities in various organs and systems along with vasculitis. Since it was reported that the presence of co-infection may cause more severe abnormalities, this study aimed to investigate the synergistic effects of co-infection on some coagulation analytes (prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and D-Dimer). Twenty dogs, all were mixed breed, aged 2-4 years, and determined to be co-infected with CVL and CME were used. As a result of the coagulation profile analyte measurements, the values of APTT, PT, and the concentration of FIB were determined to be higher in the Co-infected Group compared to the Control Group (p<0.05). Receiver operating characteristic (ROC) analysis revealed that PT (AUC: 0.980); APTT (AUC: 0.959), FIB (AUC: 1.000), and D-dimer (AUC: 0.929) had outstanding diagnostic discrimination. As a result, it was concluded that the presence of co-infection deteriorates the coagulation profile more severely in co-infection with CVL and CME.

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来源期刊

Kafkas Universitesi Veteriner Fakultesi Dergisi 农林科学-兽医学

CiteScore

1.50

自引率

14.30%

发文量

审稿时长

3-6 weeks

期刊介绍： The journal publishes full-length research papers, short communications, preliminary scientific reports, case reports, observations, letters to the editor, and reviews. The scope of the journal includes all aspects of veterinary medicine and animal science.