The Multifaceted Role of Senescence Marker Protein 30 in Health and Diseases

Q3 Pharmacology, Toxicology and Pharmaceutics
Sudisha Mukherjee, Roshan Kumar Dutta, Rinkoo Devi Gupta
{"title":"The Multifaceted Role of Senescence Marker Protein 30 in Health and Diseases","authors":"Sudisha Mukherjee, Roshan Kumar Dutta, Rinkoo Devi Gupta","doi":"10.14429/dlsj.8.18117","DOIUrl":null,"url":null,"abstract":"Senescence marker protein 30 (SMP30) is an age-linked marker protein, the expression of which declines with aging. SMP30 binds with calcium; however, the absence of a calcium-binding EF-hand motif makes it different from other calcium-binding proteins like calmodulin. Interestingly, previous studies have shown that it binds with other divalent metal co-factors also and catalyzes the cyclisation of L-gulonate required for the biosynthesis of ascorbate in non-primates. Remarkably, SMP30 is conserved among vertebrates indicating that it isa crucial protein performing certain physiological functions. Apparently, in primates, including humans, calcium homeostasis could be the primary function of SMP30 due to the absence of ascorbic acid biosynthesis in these species. In this review, we have discussed the expression pattern of SMP30 in various cells and tissues. SMP30 expression is modulated by different internal and external factors, which we have extensively discussed here. Subsequently, its role in calcium homeostasis, cell proliferation, apoptosis, and liver regeneration has also been explored. Further, the potentiality of SMP30 as a prophylactic agent against organophosphorus nerve agent poisoning has been elucidated due to its organophosphate hydrolysing activity as a promiscuous substrate.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Defence Life Science Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14429/dlsj.8.18117","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0

Abstract

Senescence marker protein 30 (SMP30) is an age-linked marker protein, the expression of which declines with aging. SMP30 binds with calcium; however, the absence of a calcium-binding EF-hand motif makes it different from other calcium-binding proteins like calmodulin. Interestingly, previous studies have shown that it binds with other divalent metal co-factors also and catalyzes the cyclisation of L-gulonate required for the biosynthesis of ascorbate in non-primates. Remarkably, SMP30 is conserved among vertebrates indicating that it isa crucial protein performing certain physiological functions. Apparently, in primates, including humans, calcium homeostasis could be the primary function of SMP30 due to the absence of ascorbic acid biosynthesis in these species. In this review, we have discussed the expression pattern of SMP30 in various cells and tissues. SMP30 expression is modulated by different internal and external factors, which we have extensively discussed here. Subsequently, its role in calcium homeostasis, cell proliferation, apoptosis, and liver regeneration has also been explored. Further, the potentiality of SMP30 as a prophylactic agent against organophosphorus nerve agent poisoning has been elucidated due to its organophosphate hydrolysing activity as a promiscuous substrate.
衰老标志蛋白30在健康和疾病中的多方面作用
衰老标记蛋白30 (SMP30)是一种与年龄相关的标记蛋白,其表达随着年龄的增长而下降。SMP30与钙结合;然而,缺乏钙结合EF-hand基序使其不同于其他钙结合蛋白,如钙调蛋白。有趣的是,先前的研究表明,它还与其他二价金属辅助因子结合,并催化非灵长类动物抗坏血酸生物合成所需的l -谷氨酸的环化。值得注意的是,SMP30在脊椎动物中是保守的,这表明它是执行某些生理功能的关键蛋白质。显然,在灵长类动物中,包括人类,钙稳态可能是SMP30的主要功能,因为这些物种缺乏抗坏血酸的生物合成。在这篇综述中,我们讨论了SMP30在各种细胞和组织中的表达模式。SMP30的表达受到不同的内部和外部因素的调节,我们在这里进行了广泛的讨论。随后,其在钙稳态、细胞增殖、细胞凋亡和肝脏再生中的作用也被探讨。此外,SMP30作为有机磷神经毒剂中毒的预防剂的潜力已被阐明,由于其作为混杂底物的有机磷水解活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Defence Life Science Journal
Defence Life Science Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
0.80
自引率
0.00%
发文量
26
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信