Vitamin D3 and the Molecular Pathway of Skin Aging

IF 0.7 Q4 PHARMACOLOGY & PHARMACY
Adeltrudis Adelsa Danimayostu, Ronny Martien, Endang Lukitaningsih, Retno Danarti
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引用次数: 0

Abstract

Many women pay attention to skin aging. Signs of aging such as lines, wrinkles, dry skin, hyperpigmentation, and loss of elasticity affect skin appearance and self-confidence. Age, lifestyle, and particularly UV irradiation stimulate reactive oxygen species (ROS) production. ROS induces the breakdown of collagen through matrix metalloproteinases (MMPs). Collagen and elastin play a pivotal role in skin aging. They maintain skin integrity, strength, and resiliency. Antioxidant and keratolytic agents are often used in anti-aging products, including several vitamins such as vitamin A, B, C and E. To date, several studies have been reported in the literature for the effects of vitamin D on collagen synthesis and MMPs inhibition. This review focuses on identifying and assessing the molecular pathways of vitamin D effects related to skin aging. The literature was collected from Google Scholar, Elsevier, Science Direct, PubMed, and Scopus databases and accessed between January 2019 and May 2022. The literature screening was conducted using keywords like “vitamin D3”, “collagen”, “matrix metalloproteinases”, “skin aging” and related to the study topic were included. The effect of vitamin D3 on MMPs inhibition (particularly on MMP-1, MMP-3, and MMP-9) has been widely published. Several studies have reported that vitamin D increases collagen synthesis and clinically improves skin elasticity. However, there have been controversial results regarding how vitamin D3 affects transforming growth factor-β (TGF-β) correlated with skin elasticity by the molecular pathway. Therefore, it can be concluded that vitamin D3 is a potential alternative agent in improving skin aging.
维生素D3与皮肤衰老的分子途径
很多女性都关注皮肤老化。衰老的迹象,如皱纹、皱纹、皮肤干燥、色素沉着和失去弹性,都会影响皮肤的外观和自信。年龄,生活方式,尤其是紫外线照射会刺激活性氧(ROS)的产生。ROS通过基质金属蛋白酶(MMPs)诱导胶原蛋白的分解。胶原蛋白和弹性蛋白在皮肤老化中起着关键作用。他们保持皮肤的完整性,力量和弹性。抗氧化剂和角化剂通常用于抗衰老产品,包括维生素A、B、C和e等几种维生素。迄今为止,文献中已经报道了维生素D对胶原合成和MMPs抑制作用的研究。这篇综述的重点是识别和评估维生素D影响皮肤衰老的分子途径。这些文献收集自谷歌Scholar、Elsevier、Science Direct、PubMed和Scopus数据库,访问时间为2019年1月至2022年5月。以“维生素D3”、“胶原蛋白”、“基质金属蛋白酶”、“皮肤老化”等关键词进行文献筛选,纳入与研究课题相关的文献。维生素D3对MMPs的抑制作用(特别是对MMP-1、MMP-3和MMP-9的抑制作用)已被广泛发表。一些研究报告称,维生素D可以增加胶原蛋白的合成,并在临床上改善皮肤弹性。然而,关于维生素D3如何通过分子途径影响与皮肤弹性相关的转化生长因子-β (TGF-β),一直存在争议的结果。因此,可以得出结论,维生素D3是一种潜在的替代剂,以改善皮肤老化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
INDONESIAN JOURNAL OF PHARMACY
INDONESIAN JOURNAL OF PHARMACY PHARMACOLOGY & PHARMACY-
CiteScore
1.20
自引率
0.00%
发文量
38
审稿时长
12 weeks
期刊介绍: The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education. The journal includes various fields of pharmaceuticals sciences such as: -Pharmacology and Toxicology -Pharmacokinetics -Community and Clinical Pharmacy -Pharmaceutical Chemistry -Pharmaceutical Biology -Pharmaceutics -Pharmaceutical Technology -Biopharmaceutics -Pharmaceutical Microbiology and Biotechnology -Alternative medicines.
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