Altered Circadian Rhythm of genes involved in Human Senescence: An Interactome Analysis

IF 0.2 Q4 Biochemistry, Genetics and Molecular Biology

Research Journal of Biotechnology Pub Date : 2023-09-15 DOI:10.25303/1810rjbt2160226

Adrija Aich, Ashish Kumar, Kavitha Thirumurugan

引用次数: 0

Abstract

Genes related to human senescence were explored to find their interaction with Circadian rhythm using Cytoscape. Upregulated genes were analyzed for functional enrichment. In Cytohubba, top 10 ranking genes were scored for attributes like MCC, degree etc. TP53 was identified as a top-ranking gene in these attributes. The cancer network was retrieved in Network analyzer of Cytohubba and merged with TP53 network. The merged network was queried for ‘cisplatin’ using STICH in Cytoscape. Enrichment analysis of cisplatin bound TP53 network showed GO process cellular response to abiotic stimulus, negative regulation of telomere capping, replicative senescence, regulation of reactive oxygen species and cellular senescence.

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参与人类衰老的基因的昼夜节律改变:相互作用组分析

利用Cytoscape研究了人类衰老相关基因与昼夜节律的相互作用。对上调基因进行功能富集分析。在Cytohubba中，对MCC、学位等属性进行排名前10位的基因评分。TP53被认为是这些属性中排名靠前的基因。在Cytohubba网络分析仪中检索肿瘤网络，并与TP53网络合并。合并后的网络在Cytoscape中使用STICH查询“顺铂”。顺铂结合TP53网络富集分析显示，氧化石墨烯参与细胞响应非生物刺激、负调控端粒盖顶、复制性衰老、调控活性氧和细胞衰老。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research Journal of Biotechnology 工程技术-生物工程与应用微生物

CiteScore

0.60

自引率

0.00%

发文量

192

审稿时长

1.5 months

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