Anesthetic and clinical assessments of I/V propofol versus ketamine in Dogs premedicated with diazepam

alexandria journal of veterinary sciences Pub Date : 2023-01-01 DOI:10.5455/ajvs.159481

Areej Shehata, Mostafa Kassem, Mahmoud Kammar, Howaida Ahmed

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Abstract

The present anesthetic investigation was aimed to evaluate anesthetic clinico-physiological and hematobiochemical effects in addition to the anesthetic properties of propofol or ketamine premedicated with diazepam . For this purpose, 12 apparently healthy dogs were randomly divided into Two groups: A and B. All dogs were premedicated with Diazepam (0.2mg/kg Bwt/IM) then intravenous anesthesia was induced in group A with propofol intravenous (1mg/kg Bwt) ,while group B with ketamine intravenous (5 mg/kg Bwt). Blood samples were collected from the Two groups 15 minutes before anesthesia induction, then at (15, 30, 45 and 60) minutes after treatments for the hemato-biochemical evaluation, and for clinico-physiological observations. A slight alteration in some physiological parameters and hemato-biochemical values was observed after anesthesia induction, but it still safe to induce general anesthesia in dogs. in conclusion, the present anesthetic investigation showed the longest period of anesthesia with complete muscle relaxation following intravenous ketamine injection than propofol in premedicated dogs with diazepam.

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异丙酚与氯胺酮对预先给药安定犬的I/V麻醉和临床评价

本研究旨在评估异丙酚或氯胺酮与地西泮预用药的麻醉临床生理和血液生化效应。将12只身体健康的犬随机分为A、B两组。所有犬均先给予地西泮(0.2mg/kg Bwt/IM)，然后静脉麻醉，A组静脉麻醉丙泊酚(1mg/kg Bwt)， B组静脉麻醉氯胺酮(5mg /kg Bwt)。两组患者分别于麻醉诱导前15分钟、麻醉诱导后15、30、45、60分钟采血，进行血液生化评价和临床生理观察。麻醉诱导后，犬的一些生理参数和血液生化指标略有改变，但全麻诱导仍然是安全的。综上所述，目前的麻醉研究表明，静脉注射氯胺酮后的麻醉时间比预先给药异丙酚的狗肌肉完全放松时间更长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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alexandria journal of veterinary sciences

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