PO17

Abstract

Purpose To investigate the relationship between dose parameters and tumor volume reduction ratio after 125I seed implantation for recurrent cervical squamous cell carcinoma, and to obtain the better parameters to predict the curative effect. Methods 26 cervical squamous cell carcinoma patients with 30 lesions were studied retrospectively in our clinic. All patients underwent dose verification immediately after operation, and obtained postoperative D90(the minimum peripheral dose accepted by 90% target volume). The patients were followed up regularly. According to the CT images during the actual follow-up, the tumor volume reduction ratio at the end of t months (Rt),the tumor volume reduction ratio 1 month after operation (R1), the first month actual absorbed dose (D1m), the first month efficacy corrected absorbed dose (D1e), the first month sensitivity corrected absorbed dose (D1s) and the t months actual absorbed dose (Dt) were calculated. Curve fitting was performed for postoperative D90 and R1, and curve fitting was performed for postoperative D90, D1m, D1e, D1s and Rt to find the correlation between each parameter and tumor volume reduction ratio. Results The mean values of D90,D1m,D1e,D1s,Rt,R1were (105.4±22.8) Gy,(30.9±7.4)Gy,(37.1±8.9)Gy,(37.8±11.6)Gy,(39.4±17)%,(20.4±12)%. Postoperative D90 and R1, postoperative D90, D1m, D1e, D1s andRt all have positive relationship. The equations are as follows y=6.856×10-7x3-2.66×10-4x2+0.031x-0.879(R2=0.139),y=1.573×10-6x3-4.47×10-4x2+0.045x-0.967(R2=0.027),y=7.11×10-5x3-0.07x2+0.193x-1.402(R2=0.043),y=3.546×10-5x3-0.003x2+0.108x-0.744(R2=0.126),y=1.022×10-5x3-0.001x2+0.048x-0.275(R2=0.243). Conclusion PostoperativeD90, D1m, D1e and D1s were positively correlated with postoperative tumor volume reduction ratio, which can be used to predict the efficacy of primary recurrent cervical squamous cell carcinoma patients with particle implantation. Compared with D90 and D1m, and D1e , D1s can be better predictors . To investigate the relationship between dose parameters and tumor volume reduction ratio after 125I seed implantation for recurrent cervical squamous cell carcinoma, and to obtain the better parameters to predict the curative effect. 26 cervical squamous cell carcinoma patients with 30 lesions were studied retrospectively in our clinic. All patients underwent dose verification immediately after operation, and obtained postoperative D90(the minimum peripheral dose accepted by 90% target volume). The patients were followed up regularly. According to the CT images during the actual follow-up, the tumor volume reduction ratio at the end of t months (Rt),the tumor volume reduction ratio 1 month after operation (R1), the first month actual absorbed dose (D1m), the first month efficacy corrected absorbed dose (D1e), the first month sensitivity corrected absorbed dose (D1s) and the t months actual absorbed dose (Dt) were calculated. Curve fitting was performed for postoperative D90 and R1, and curve fitting was performed for postoperative D90, D1m, D1e, D1s and Rt to find the correlation between each parameter and tumor volume reduction ratio. The mean values of D90,D1m,D1e,D1s,Rt,R1were (105.4±22.8) Gy,(30.9±7.4)Gy,(37.1±8.9)Gy,(37.8±11.6)Gy,(39.4±17)%,(20.4±12)%. Postoperative D90 and R1, postoperative D90, D1m, D1e, D1s andRt all have positive relationship. The equations are as follows y=6.856×10-7x3-2.66×10-4x2+0.031x-0.879(R2=0.139),y=1.573×10-6x3-4.47×10-4x2+0.045x-0.967(R2=0.027),y=7.11×10-5x3-0.07x2+0.193x-1.402(R2=0.043),y=3.546×10-5x3-0.003x2+0.108x-0.744(R2=0.126),y=1.022×10-5x3-0.001x2+0.048x-0.275(R2=0.243). PostoperativeD90, D1m, D1e and D1s were positively correlated with postoperative tumor volume reduction ratio, which can be used to predict the efficacy of primary recurrent cervical squamous cell carcinoma patients with particle implantation. Compared with D90 and D1m, and D1e , D1s can be better predictors .