The Association of Sugar and Sugar Substitutes to Breast, Lung, and Oral Cancer Cell Lines: A Scoping Review

IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL

International Medical Journal Malaysia Pub Date : 2023-10-01 DOI:10.31436/imjm.v22i4.2152

Mukarramah Zainal, Nur Sabrina Md Asri, Nur Sabrina Mohamed Faizal, Hasnah Begum Said Gulam Khan, Wan Nurhazirah Wan Ahmad Kamil, Nurul ‘Izzah Mohd Sarmin, Noor Kaslina Mohd Kornain, Mohd Hafiz Arzmi

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引用次数: 0

Abstract

Cancer which synonymously known as neoplasia is a genetic disorder of cell growth that is triggered by acquired or less commonly inherited mutations affecting a single cell and its clonal progeny. The aims of this scoping review was to investigate the role of sugar and sugar substitutes in breast, lung, and oral cancers with a hypothesis that sugar promoted carcinogenesis. Three databases (EBSCO, PubMed, and Scopus) were searched from January 2010 to December 2021 to identify the preclinical studies eligible for this scoping review. The review was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Scoping Reviews (PRISMA-ScR) guidelines. A total of 361 articles were reviewed and the qualitative synthesis used 12 of these articles. Based on the qualitative synthesis, four studies reported dietary sugar (glucose- and/or sucrose) induced cancer progression, one study revealed sugar substitute (aspartame) induced cancer proliferation, seven studies reported that sugar substitutes inhibit cancer proliferation, and one study reported that sucrose promotes cancer while xylitol inhibits cancer. In addition., it was reported that D-allose and cisplatin have a synergistic effect in treating cancer. In conclusion, simple sugar intake is associated with an increased risk of carcinogenesis. In contrast, sugar substitutes inhibit cancer cell line progression, subsequently acting as a potential cancer therapy, thus supporting the study's hypothesis.

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糖和糖替代品与乳腺癌、肺癌和口腔癌细胞系的关系:一项范围综述

癌症，同义称为肿瘤，是一种细胞生长的遗传性疾病，由影响单个细胞及其克隆后代的获得性或不太常见的遗传突变引发。本综述的目的是研究糖和糖替代品在乳腺癌、肺癌和口腔癌中的作用，并假设糖促进了癌变。检索了2010年1月至2021年12月的三个数据库(EBSCO、PubMed和Scopus)，以确定符合本范围评价的临床前研究。根据系统评价和荟萃分析范围评价的首选报告项目(PRISMA-ScR)指南进行评价。共综述了361篇文献，其中12篇进行了定性合成。在定性合成的基础上，四项研究报告了膳食糖(葡萄糖和/或蔗糖)诱导癌症进展，一项研究表明糖替代品(阿斯巴甜)诱导癌症增殖，七项研究报告糖替代品抑制癌症增殖，一项研究报告蔗糖促进癌症而木糖醇抑制癌症。此外。，有报道称D-allose和顺铂在治疗癌症方面具有协同作用。总之，摄入单糖会增加致癌风险。相比之下，糖替代品抑制癌细胞系的进展，随后作为一种潜在的癌症治疗方法，从而支持该研究的假设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Medical Journal Malaysia Medicine-Medicine (all)

CiteScore

0.40

自引率

0.00%

发文量

期刊介绍： International Medical Journal Malaysia (IMJM) is the official journal of the Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia. It serves primarily as a forum for education and intellectual discourse for health professionals namely in clinical medicine but covers diverse issues relating to medical ethics, professionalism as well as medical developments and research in basic medical sciences. It also serves the unique purpose of highlighting issues and research pertaining to the Muslim world. Contributions to the IMJM reflect its international and multidisciplinary readership and include current thinking across a range of specialties, ethnicities and societies.