Improved Quality of Healed Wounds with Topical Application of Eurycoma Longifolia Jack Root Extract Hydrogel

IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL
Maryam Riyadh Yaseen Al-Bayati, Ghasak Ghazi Faisal, Azliana Abd Fuaat, Khairunisa Ahmad Affandi, Batoul Alallam
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引用次数: 0

Abstract

INTRODUCTION: Collagen is the key component of the extracellular matrix that plays a critical role in the strength and quality of the healed wound. Eurycoma longifolia Jack root extract (TA) has been documented as an anti-inflammatory, antioxidant, and antimicrobial agent that may improve the quality of healed wounds. The objective of this study is to investigate the effect of topical application of TA hydrogel on the quality of the healed skin in rats. MATERIALS AND METHODS: Twenty male Sprague Dawley rats were grouped into 4 groups: Negative control, Hydrocyn® aqua gel positive control, vehicle (Xanthan) hydrogel, and Eurycoma longifolia Jack (TA) hydrogel. Treatments were applied twice daily starting on wounding day until day 21. An excisional wound was created on the back of 20 rats. Tissue samples of the healed skin were collected for histological examination by measuring the epidermal and dermal thicknesses and evaluating the collagen fibre quality by VVG stain. RESULTS: The TA hydrogel group had the thickest newly formed epidermis compared with the other experimental groups. For the dermal thickness, compared with the vehicle (xanthan) hydrogel group, TA hydrogel, and Hydrocyn aqua® gel positive control groups showed significantly increased thickness with p values 0.020 and 0.045, respectively. Histologically TA hydrogel group showed a significant increase in mixed-oriented collagen fibres, and fascicular collagen bundles and showed profound collagen density. CONCLUSION: TA hydrogel improved the quality of healed skin by increasing the epidermal/dermal thicknesses and enhancing the quality of newly produced collagen fibres. It can be considered a promising and effective wound-healing agent.
局部应用鸢尾提取物水凝胶改善创面愈合质量
胶原蛋白是细胞外基质的关键成分,在愈合伤口的强度和质量中起着关键作用。长叶Eurycoma longifolia杰克根提取物(TA)已被证明是一种抗炎,抗氧化和抗菌剂,可以改善愈合伤口的质量。本研究旨在探讨TA水凝胶外用对大鼠皮肤愈合质量的影响。材料与方法:雄性Sprague Dawley大鼠20只,随机分为4组:阴性对照组、Hydrocyn®水凝胶阳性对照组、载体(黄原胶)水凝胶组和长叶Eurycoma longifolia Jack (TA)水凝胶组。从受伤日起至第21天,每日2次。在20只大鼠的背部留下了一个切除伤口。取愈合后皮肤组织标本进行组织学检查,测定表皮和真皮厚度,用VVG染色法评价胶原纤维质量。结果:与其他实验组相比,TA水凝胶组新生表皮厚度最大。真皮厚度方面,与载体(黄原胶)水凝胶组相比,TA水凝胶组和Hydrocyn aqua®凝胶阳性对照组的真皮厚度显著增加(p值分别为0.020和0.045)。组织学上,TA水凝胶组混合取向胶原纤维和束状胶原束明显增加,胶原密度较深。结论:TA水凝胶通过增加表皮/真皮厚度和提高新生成胶原纤维的质量来改善皮肤愈合质量。它可以被认为是一种有前途和有效的伤口愈合剂。
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来源期刊
International Medical Journal Malaysia
International Medical Journal Malaysia Medicine-Medicine (all)
CiteScore
0.40
自引率
0.00%
发文量
73
期刊介绍: International Medical Journal Malaysia (IMJM) is the official journal of the Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia. It serves primarily as a forum for education and intellectual discourse for health professionals namely in clinical medicine but covers diverse issues relating to medical ethics, professionalism as well as medical developments and research in basic medical sciences. It also serves the unique purpose of highlighting issues and research pertaining to the Muslim world. Contributions to the IMJM reflect its international and multidisciplinary readership and include current thinking across a range of specialties, ethnicities and societies.
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