Hemoglobin E Prevalence among People Residing in Malaria Areas

IF 0.4 4区农林科学 Q4 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Indian Journal of Animal Research Pub Date : 2023-10-23 DOI:10.18805/ijar.bf-1685

Murad A. Mubaraki, Mohammed A. Haijan, Majed Ahmed Adawi, Taghreed A. Hafiz, Rewaida Abdel-Gaber, Saeed El-Ashram, Mohamed A. Dkhil

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Abstract

Background: Malaria can infect erythrocytes and hence cause different pathogenesis episodes leading to death mostly in pregnant women and children under the age of 5 years. The selective pressure of these parasites leads to the production of new human genetic diseases. The most prevalent genetic alterations in the human genome are thalassemia and hemoglobinopathies (Hb E, Hb S), which are recognized throughout the world, including Saudi Arabia. Methods: From May 2018 to August 2019, 13972 Saudi citizens from King Fahd Central Hospital and premarital facilities in the Saudi Arabian province of Jazan participated in this study. This study aims to compare the prevalence of Hb E and other hemoglobinopathies in positive versus negative cases of malaria. So, CBC, malaria test, Hb-electrophoresis, and molecular study were investigated. Result: For thalassemias and Hb disorders, 36% with abnormal Hb (47% of them) carried Hb S in their blood, 37% with á-thalassemia, 11% for â-thalassemia and 4% of Hb E. Significant variations in CBC parameters were observed in Hb E patients. There was significant decrease in MCV, MCH and MCHC and slightly increase in WBCs, RBCs, RDW and PLT as compared to controls.

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疟疾地区居民血红蛋白E患病率

背景:疟疾可感染红细胞，因此引起不同的发病机制，导致死亡，主要发生在孕妇和5岁以下儿童中。这些寄生虫的选择压力导致新的人类遗传疾病的产生。人类基因组中最普遍的基因改变是地中海贫血和血红蛋白病(Hb E, Hb S)，这是全世界公认的，包括沙特阿拉伯。方法:2018年5月至2019年8月，来自沙特阿拉伯吉赞省法赫德国王中心医院和婚前设施的13972名沙特公民参与了本研究。本研究的目的是比较乙肝病毒和其他血红蛋白病的流行率在阳性和阴性疟疾病例。因此，对CBC、疟疾检测、hb电泳和分子研究进行了研究。结果:在地中海贫血和Hb疾病中，36%的Hb异常患者(其中47%)血液中携带Hb S, 37%的Hb异常患者(á-thalassemia)， 11%的Hb异常患者(-地中海贫血)和4%的Hb E异常患者(Hb E)血液中携带Hb S。与对照组相比，MCV、MCH和MCHC显著降低，白细胞、红细胞、RDW和PLT略有增加。

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来源期刊

Indian Journal of Animal Research AGRICULTURE, DAIRY & ANIMAL SCIENCE-

CiteScore

1.00

自引率

20.00%

发文量

332

审稿时长

6 months

期刊介绍： The IJAR, the flagship print journal of ARCC, it is a monthly journal published without any break since 1966. The overall aim of the journal is to promote the professional development of its readers, researchers and scientists around the world. Indian Journal of Animal Research is peer-reviewed journal and has gained recognition for its high standard in the academic world. It anatomy, nutrition, production, management, veterinary, fisheries, zoology etc. The objective of the journal is to provide a forum to the scientific community to publish their research findings and also to open new vistas for further research. The journal is being covered under international indexing and abstracting services.