PHARMACOKINETIC MARKER GENES OF PATIENTS WITH SEVERE SCHIZOPHRENIA RESISTANT TO ANTIPSYCHOTIC THERAPY

Abstract

The response to drug therapy is determined by the genetic characteristics of pharmacokinetic and pharmacodynamic processes in the human body. The study of the relationship between genetic factors and the resistance of patients with severe outcome is necessary to understand the causes of the formation of this endophenotype of schizophrenia. Our analysis showed a more frequent combination of a severe outcome of schizophrenia with alleles of genes that control the peripheral metabolism of xenobiotics and cause the pharmacokinetic processes of antipsychotic therapy.