Hamza Elbouny, Brahim Ouahzizi, Mohamed Bammou, Khalid Sellam, Chakib Alem
{"title":"Anti-hyperlipidemic and Antioxidant Potential of Phenolic Monoterpenes Rich <i>Thymus satureioides</i> Coss. Volatile Oil","authors":"Hamza Elbouny, Brahim Ouahzizi, Mohamed Bammou, Khalid Sellam, Chakib Alem","doi":"10.1080/22311866.2023.2277899","DOIUrl":null,"url":null,"abstract":"AbstractThis work aims to evaluate the antioxidant and lipid-lowering effects of the essential oil of Thymus satureioides and its main compounds. The profile of volatile phytochemicals was determined by gas chromatography-mass spectrometry (GC/MS). Total phenolic compounds estimation and antioxidant activity assessment have been evaluated according to the literature models and the anti-hyperlipidemic activity was evaluated using triton wr-1339 induced hyperlipidemic rats model. Our findings revealed that thymol (26.6%) and carvacrol (25.9%) were the most abundant volatile constituents. Furthermore, the essential oil was found to be rich in phenolic components (6.50 ±0.14 GAE mg/g EO) and exhibits significant antioxidant potential (DPPH IC50=25.02 mg/mL; ABTS IC50=0.87 mg/mL). Additionally, the volatile oil displayed a potent lipid-lowering potential by reducing the levels of triglycerides (-68.78%), cholesterol (-36.34%), and non-HDL-C (-38.44%). This effect can be explained by its richness in thymol and carvacrol, which demonstrated a comparable anti-hyperlipidemic effect to that of simvastatin. We conclude that Thymus satureioides is a natural producer of lipid-lowering agents that can be used as a potential natural alternative treatment for managing hyperlipidemia.Keywords: Thymus satureioidesvolatile oilthymolcarvacrolhyperlipidemia","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":"57 1","pages":"0"},"PeriodicalIF":0.9000,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biologically Active Products from Nature","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/22311866.2023.2277899","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
AbstractThis work aims to evaluate the antioxidant and lipid-lowering effects of the essential oil of Thymus satureioides and its main compounds. The profile of volatile phytochemicals was determined by gas chromatography-mass spectrometry (GC/MS). Total phenolic compounds estimation and antioxidant activity assessment have been evaluated according to the literature models and the anti-hyperlipidemic activity was evaluated using triton wr-1339 induced hyperlipidemic rats model. Our findings revealed that thymol (26.6%) and carvacrol (25.9%) were the most abundant volatile constituents. Furthermore, the essential oil was found to be rich in phenolic components (6.50 ±0.14 GAE mg/g EO) and exhibits significant antioxidant potential (DPPH IC50=25.02 mg/mL; ABTS IC50=0.87 mg/mL). Additionally, the volatile oil displayed a potent lipid-lowering potential by reducing the levels of triglycerides (-68.78%), cholesterol (-36.34%), and non-HDL-C (-38.44%). This effect can be explained by its richness in thymol and carvacrol, which demonstrated a comparable anti-hyperlipidemic effect to that of simvastatin. We conclude that Thymus satureioides is a natural producer of lipid-lowering agents that can be used as a potential natural alternative treatment for managing hyperlipidemia.Keywords: Thymus satureioidesvolatile oilthymolcarvacrolhyperlipidemia