Dietary fructose enhances the development of atypical acinar cell nodules in the pancreas of rats pretreated with N-nitrosomorpholine.

Archiv fur Geschwulstforschung Pub Date : 1990-01-01
H Enzmann, T Dettler, D Ohlhauser, H Stumpf, P Bannasch
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Abstract

Dietary influences on carcinogenesis have been shown in various tissues on the basis of epidemiological and experimental approaches. The present paper demonstrates that the oral application of fructose over long periods to rats previously treated with N-nitrosomorpholine increases the incidence of atypical acinar cell nodules (AACN) in the pancreas. Whereas an increase in AACN was statistically significant (P less than 0.005), no effect on ductule-like structures was detectable. AACN have been regarded as precursor lesions of the acinar cell carcinoma. Although the AACN observed frequently exhibited severe atypia and numerous mitotic figures, no clearcut evidence for malignancy could be detected under our experimental conditions.

膳食果糖促进了n -亚硝基吗啡预处理大鼠胰腺非典型腺泡细胞结节的发展。
在流行病学和实验方法的基础上,饮食对各种组织的致癌作用已经得到证实。本论文表明,长期口服果糖给先前用n -亚硝基吗啡治疗的大鼠增加了胰腺非典型腺泡细胞结节(AACN)的发生率。虽然AACN的增加有统计学意义(P < 0.005),但对小管样结构没有影响。AACN被认为是腺泡细胞癌的前驱病变。虽然观察到的AACN经常表现出严重的非典型性和大量的有丝分裂图,但在我们的实验条件下,没有明确的恶性证据。
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