Changes in brain activation measured by functional Near-Infrared Spectroscopy associated with continuing to play following sport-related concussion among adolescent athletes

Pub Date : 2023-10-23 DOI:10.7358/neur-2023-034-trbo

Alicia M. Trbovich, Patrick J. Sparto, Theodore J. Huppert, R.J. Elbin, Alicia M. Kissinger-Knox, Daniel Charek, Michael W. Collins, Anthony P. Kontos

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Abstract

Athletes who continue to play following sport-related concussion (SRC) have worse clinical outcomes compared to those removed from play immediately. This prospective study examined brain activation (i.e., oxygenated hemoglobin concentration [HbO2]), using functional near-infrared spectroscopy (fNIRS), in 20 adolescent athletes who either continued to play (PLAYED) or were immediately removed (REMOVED) following SRC. A linear mixed effects model found the PLAYED group demonstrated an increase of [HbO2] in the left hemisphere at the initial visit (pFDR<.001) and the REMOVED group had a reduction in [HbO2] in the right hemisphere at clinical recovery (pFDR=0.024). There was a significant group*timepoint interaction (pFDR<0.011), in which the PLAYED group had greater increase in [HbO2] in the left hemisphere at the initial visit compared with the REMOVED group, but no differences at clinical recovery. Athletes who remain in play following SRC exhibited more pronounced brain hyperactivation, which may be associated with worse clinical recovery outcomes.

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用功能性近红外光谱测量青少年运动员在运动相关脑震荡后继续比赛的大脑激活变化

运动相关脑震荡(SRC)后继续比赛的运动员与立即退出比赛的运动员相比，临床结果更差。这项前瞻性研究使用功能性近红外光谱(fNIRS)检测了20名青少年运动员的大脑活动(即含氧血红蛋白浓度[HbO2])，这些运动员在SRC后要么继续比赛(play)，要么立即被移除(removed)。线性混合效应模型发现，在首次就诊时，play组左半球[HbO2]升高(pFDR<.001)，而在临床恢复时，remove组右半球[HbO2]降低(pFDR=0.024)。组与时间点之间存在显著的相互作用(pFDR<0.011)，其中，与REMOVED组相比，play组在初次就诊时左半球[HbO2]增加更大，但在临床恢复时无差异。SRC后继续比赛的运动员表现出更明显的大脑过度激活，这可能与更差的临床恢复结果有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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