Rationality of Cytoflavin Inclusion in the Treatment of Patients with Dermatological Pathology Comorbid with Mental Disorders

Abstract

With the help of literature data, the effectiveness of Cytoflavin inclusion in the treatment regimens for patients with psoriasis, microbial eczema, and rosacea in the period of exacerbation was analyzed based on the assessment of subjective and objective data of the DLQI (Dermatology Life Quality Index), WAM (Well-being, Activity, Mood), DISS (Dermatological Index of the Symptom Scale). It was revealed that, according to the results of testing before the start of treatment, all patients had mental disorders, which manifested in an increase in indicators on the DLQI and DISS scales and a decrease on the WAM scale. The reduction of clinical manifestations and the decrease in DISS (by 86.0%, (P≤0.05) for rosacea, by 83.0% (P≤0.01) for eczema) was found to be more pronounced after a course of therapy with the inclusion of Cytoflavin (2 tablets 2 times a day 30 minutes before meals, course — 25 days), compared with standard therapy. This had a positive effect on well-being (the value of the indicator increased by 63,9% for rosacea, by 66,0% for eczema, and 27.8% for psoriasis), activity (56,1% for rosacea, 66.1 % for eczema, and 22.1% for psoriasis), mood (51,9% for rosacea, 54.3% for eczema, and 23.7% for psoriasis), and improved quality of life: indicator DLQI decreased by 42,9% in rosacea, 62.4% in eczema, and 61.5% in psoriasis. Thus, the analysis of literature data made it possible to confirm that the inclusion of Cytoflavin in the treatment regimens for patients with the above-mentioned skin pathologies, comorbid with mental disorders, improves the effectiveness of basic therapy, which is manifested by a faster and more pronounced reduction in clinical manifestations and an increase in the quality of life of patients.