"The Physiological Mechanism of Extracellular Calcium- Sensing Receptor Action in the Regulation of Vascular Tone and Blood Pressure"

Abstract

Calcium is the fifth most abundant element in the adult human body. The free ionized calcium (Ca2+) is responsible for a variety of physiological processes and tightly maintained mainly by action of calciotropic hormones and other nutrients. Calcium-sensing receptor (CaSR/CaR) is a cell-surface receptor that responds to, or “senses,” extracellular Ca²⁺ concentrations in parathyroid, kidney and other tissues. The aim of the review is to get into the fine details of physiologic mechanisms responsible for extracellular calcium-sensing receptor actions in the regulation of vascular tone and blood pressure.